Journal article

Publication year: 2021

Pages: 4587-4593

Journal: Journal of Neurology

Volume number: 268

Issue number: 12

ISSN: 0340-5354

eISSN: 1432-1459

DOI Link: https://doi.org/10.1007/s00415-020-10275-x

Publisher: Springer

Abstract: 
Background Multiple sclerosis (MS) is a complex autoimmune disorder characterized by neurologic dysfunction. The symptoms worsen as the disease progresses to the relapsing stage. Aim This study aimed to examine the role of T cells in MS pathogenesis. Materials and methods The review was performed based on articles obtained from PsycINFO, PubMed, Web of Science, and CINAHL. Search terms and phrases, such as "multiple sclerosis," "MS," "T cells," "development," "Dysregulated T cells," and "Effector T cells", were used to identify articles that could help explore the research topic. Results The pathogenesis of MS is linked to the regulatory, inflammatory, suppressive, and effector roles of T cells. However, the actual roles of specific T cell subsets in MS development are not well understood. Discussion The study revealed a significant link between MS and T cell activity. Targeting T cells is a potential strategy for the development of new therapies to manage MS. Conclusion MS is a complex demyelinating condition that affects several million people around the world. Research has revealed that various classes of T cells, including effector T cells and regulatory T cells, influence the development and progression of MS. Further investigations are required to elucidate the underlying mechanisms through which specific T cell populations influence MS pathogenesis.

Harvard Citation style: Arneth, B. (2021) Contributions of T cells in multiple sclerosis: what do we currently know?, Journal of Neurology, 268(12), pp. 4587-4593. https://doi.org/10.1007/s00415-020-10275-x

APA Citation style: Arneth, B. (2021). Contributions of T cells in multiple sclerosis: what do we currently know?. Journal of Neurology. 268(12), 4587-4593. https://doi.org/10.1007/s00415-020-10275-x