Journalartikel

Jahr der Veröffentlichung: 2020

Seiten: 1118-1125

Zeitschrift: The Journal of Heart and Lung Transplantation

Bandnummer: 39

Heftnummer: 10

ISSN: 1053-2498

eISSN: 1557-3117

DOI Link: https://doi.org/10.1016/j.healun.2020.06.014

Verlag: Elsevier

Abstract: 

BACKGROUND: The updated hemodynamic definition of pulmonary hypertension (PH) due to interstitial lung disease (ILD) differentiates severe and non-severe phenotypes, but no further risk stratification strategy has been established or validated for severe PH due to ILD. We aimed to assess the prognostic value of a truncated version of the European Society of Cardiology/European Respiratory Society (ESC/ERS) PH risk stratification scheme in severe PH due to ILD.

METHODS: We retrospectively analyzed 185 patients with severe PH (mean pulmonary artery pressure of >= 35 mm Hg or >= 25 mm Hg with cardiac index <2.0 liter/min/m(2)) due to ILD who were enrolled in the Giessen PH Registry after being referred for invasive diagnostic work-up of suspected PH during 1995-2018. A truncated ESC/ERS risk stratification scheme (based on 8 parameters from the full scheme) was applied. Kaplan-Meier and univariate Cox regression analyses were used to evaluate transplant-free survival and hazard ratios, respectively.

RESULTS: During follow-up (median [interquartile range]: 19 [7-40] months), 146 events occurred. Using baseline data for risk stratification, 5-year transplant-free survival of low-, intermediate-, and high-risk groups was 43%, 15%, and 4%, respectively (log-rank p = 0.010; hazard ratio of high- vs low-risk group: 3.116 [95% CI: 1.428-6.800]). Using follow-up data (at 11 [6.0-32.5] months) for risk stratification, 5-year survival of low-, intermediate-, and high-risk groups was 22%, 3%, and 0%, respectively (log-rank p = 0.005).

CONCLUSIONS: The truncated ESC/ERS scheme was clinically useful and demonstrated prognostic relevance in severe PH due to ILD. (C) 2020 International Society for Heart and Lung Transplantation. All rights reserved.

Harvard-Zitierstil: Yogeswaran, A., Tello, K., Faber, M., Sommer, N., Kuhnert, S., Seeger, W., et al. (2020) Risk assessment in severe pulmonary hypertension due to interstitial lung disease, The Journal of Heart and Lung Transplantation, 39(10), pp. 1118-1125. https://doi.org/10.1016/j.healun.2020.06.014

APA-Zitierstil: Yogeswaran, A., Tello, K., Faber, M., Sommer, N., Kuhnert, S., Seeger, W., Grimminger, F., Ghofrani, H., Richter, M., & Gall, H. (2020). Risk assessment in severe pulmonary hypertension due to interstitial lung disease. The Journal of Heart and Lung Transplantation. 39(10), 1118-1125. https://doi.org/10.1016/j.healun.2020.06.014