Journalartikel

Jahr der Veröffentlichung: 2020

Seiten: F469-F475

Zeitschrift: American Journal of Physiology - Renal Physiology

Bandnummer: 319

Heftnummer: 3

ISSN: 1931-857X

eISSN: 1522-1466

Open Access Status: Bronze

DOI Link: https://doi.org/10.1152/ajprenal.00257.2020

Verlag: American Physiological Society

Abstract: 
A lower 24-h urine pH (24h-pH), i.e., a higher renal excretion of free protons. at a given acid load to the body, denotes a reduction in the kidney's capacity for net acid excretion (NAE). There is increasing evidence, not only for patients with type 2 diabetes but also for healthy individuals. that higher body fatness or waist circumference (WC) has a negative impact on renal function to excrete acids (NAE). We hypothesized that adiposity-related inflammation molecules might mediate this relation between adiposity and renal acid excretion function. Twelve biomarkers of inflammation were measured in fasting blood samples from 162 adult participants (18-25 yr old) of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study who had undergone anthropometric measurements and collected 24-h urine samples. Both Baron and Kenny's (B&K's) steps to test mediation and causal mediation analysis were conducted to examine the potential mediatory roles of biomarkers of inflammation in the WC-24-h pH relationship after strictly controlling for laboratory-measured NAE. In B&K's mediation analysis. leptin. soluble intercellular adhesion molecule 1 (sICAM-1), and adiponectin significantly associated with the outcome 24-h pH and attenuated the WC-pH relation. In agreement herewith, causal mediation analysis estimated the "natural indirect effects" of WC on 24-h pH via leptin (P = 0.01) and adiponectin (P = 0.03) to be significant. with a trend for sICAM-1 (P = 0.09). The calculated proportions mediated by leptin, adiponectin, and sICAM-1 were 64%, 23%. and 12%, respectively. Both mediation analyses identified an inflammatory cytokine (leptin) and an anti-inflammatory cytokine (adiponectin) along with sICAM-1 as being potentially involved in mediating adiposity-related influences on renal acid excretion capacity.

Harvard-Zitierstil: Hua, Y., Herder, C., Kalhoff, H., Buyken, A., Esche, J., Krupp, D., et al. (2020) Inflammatory mediators in the adipo-renal axis: leptin, adiponectin, and soluble ICAM-1, American Journal of Physiology - Renal Physiology, 319(3), pp. F469-F475. https://doi.org/10.1152/ajprenal.00257.2020

APA-Zitierstil: Hua, Y., Herder, C., Kalhoff, H., Buyken, A., Esche, J., Krupp, D., Wudy, S., & Remer, T. (2020). Inflammatory mediators in the adipo-renal axis: leptin, adiponectin, and soluble ICAM-1. American Journal of Physiology - Renal Physiology. 319(3), F469-F475. https://doi.org/10.1152/ajprenal.00257.2020