Galectin-3, GDF-15, and sST2 for the assessment of disease severity and therapy response in patients suffering from inoperable chronic thromboembolic pulmonary hypertension - Forschungsportal der Justus-Liebig-Universität Gießen:

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Galectin-3, GDF-15, and sST2 for the assessment of disease severity and therapy response in patients suffering from inoperable chronic thromboembolic pulmonary hypertension

Autorenliste: Kriechbaum, Steffen D.; Wiedenroth, Christoph B.; Peters, Karina; Barde, Marta A.; Ajnwojner, Ruth; Wolter, Jan-Sebastian; Haas, Moritz; Roller, Fritz C.; Guth, Stefan; Rieth, Andreas J.; Rolf, Andreas; Hamm, Christian W.; Mayer, Eckhard; Keller, Till; Liebetrau, Christoph

Jahr der Veröffentlichung: 2020

Seiten: 578-586

Zeitschrift: Biomarkers

Bandnummer: 25

Heftnummer: 7

ISSN: 1354-750X

eISSN: 1366-5804

DOI Link: https://doi.org/10.1080/1354750X.2020.1821776

Verlag: Taylor and Francis Group

Abstract:
Purpose This study examined sST2, GDF-15, and galectin-3 as indicators of disease severity and therapy response in chronic thromboembolic pulmonary hypertension (CTEPH). Methods This study included 57 inoperable CTEPH patients who underwent balloon pulmonary angioplasty and 25 controls without cardiovascular disease. Biomarker levels were examined in relation to advanced hemodynamic impairment [tertile with worst right atrial pressure (RAP) and cardiac index], hemodynamic therapy response [normalized hemodynamics (meanPAP <= 25 mmHg, PVR <= 3 WU and RAP <= 6 mmHg) or a reduction of meanPAP >= 25%; PVR >= 35%, RAP >= 25%]. Results GDF-15 [820 (556-1315) pg/ml vs. 370 (314-516) pg/ml;p < 0.001] and sST2 [53.7 (45.3-74.1) ng/ml vs. 48.7 (35.5-57.0) ng/ml; p = 0.02] were higher in CTEPH patients than in controls. At baseline, a GDF-15 level >= 1443 pg/ml (AUC 0.88; OR 31.4) and a sST2 level >= 65 ng/ml (AUC 0.80; OR 10.9) were associated with advanced hemodynamic impairment. At follow-up GDF-15 <= 958 pg/ml (AUC = 0.74, OR 18) identified patients with optimal hemodynamic therapy response and <= 760 pg/ml (AUC = 0.79, OR 14). Conclusion GDF-15 and sST2 levels are higher in CTEPH and identified patients with advanced hemodynamic impairment. Further, decreased GDF-15 levels at follow-up were associated with hemodynamic therapy response. The diagnostic strength was not superior to NT-proBNP.

Zitierstile

Harvard-Zitierstil: Kriechbaum, S., Wiedenroth, C., Peters, K., Barde, M., Ajnwojner, R., Wolter, J., et al. (2020) Galectin-3, GDF-15, and sST2 for the assessment of disease severity and therapy response in patients suffering from inoperable chronic thromboembolic pulmonary hypertension, Biomarkers, 25(7), pp. 578-586. https://doi.org/10.1080/1354750X.2020.1821776

APA-Zitierstil: Kriechbaum, S., Wiedenroth, C., Peters, K., Barde, M., Ajnwojner, R., Wolter, J., Haas, M., Roller, F., Guth, S., Rieth, A., Rolf, A., Hamm, C., Mayer, E., Keller, T., & Liebetrau, C. (2020). Galectin-3, GDF-15, and sST2 for the assessment of disease severity and therapy response in patients suffering from inoperable chronic thromboembolic pulmonary hypertension. Biomarkers. 25(7), 578-586. https://doi.org/10.1080/1354750X.2020.1821776

Zitierstile

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