Journalartikel

Jahr der Veröffentlichung: 2020

Zeitschrift: Cells

Bandnummer: 9

Heftnummer: 8

eISSN: 2073-4409

Open Access Status: Gold

DOI Link: https://doi.org/10.3390/cells9081875

Verlag: MDPI

Abstract: 
More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH), leading to a significant increase in total morbidity and mortality. Until today, there is no curative therapy for both BPD and BPD-PH available. It has become increasingly evident that growth factors are playing a central role in normal and pathologic development of the pulmonary vasculature. Thus, this review aims to summarize the recent evidence in our understanding of BPD-PH from a basic scientific point of view, focusing on the potential role of Fibroblast Growth Factor (FGF)/FGF10 signaling pathway contributing to disease development, progression and resolution.

Harvard-Zitierstil: Chao, C., Chong, L., Chu, X., Shrestha, A., Behnke, J., Ehrhardt, H., et al. (2020) Targeting Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension (BPD-PH): Potential Role of the FGF Signaling Pathway in the Development of the Pulmonary Vascular System, Cells, 9(8), Article 1875. https://doi.org/10.3390/cells9081875

APA-Zitierstil: Chao, C., Chong, L., Chu, X., Shrestha, A., Behnke, J., Ehrhardt, H., Zhang, J., Chen, C., & Bellusci, S. (2020). Targeting Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension (BPD-PH): Potential Role of the FGF Signaling Pathway in the Development of the Pulmonary Vascular System. Cells. 9(8), Article 1875. https://doi.org/10.3390/cells9081875