Journal article

Publication year: 2020

Pages: 5413-5431

Journal: British Journal of Pharmacology

Volume number: 177

Issue number: 23

ISSN: 0007-1188

eISSN: 1476-5381

Open access status: Hybrid

DOI Link: https://doi.org/10.1111/bph.14992

Publisher: Wiley

Abstract: 
Ischaemic and pharmacological conditioning of the left ventricle is mediated by the activation of signalling cascades, which finally converge at the mitochondria and reduce ischaemia/reperfusion (I/R) injury. Whereas the molecular mechanisms of conditioning in the left ventricle are well characterized, cardioprotection of the right ventricle is principally feasible but less established. Similar to what is known for the left ventricle, a dysregulation in signalling pathways seems to play a role in I/R injury of the healthy and failing right ventricle and in the ability/inability of the right ventricle to respond to a conditioning stimulus. The maintenance of mitochondrial function seems to be crucial in both ventricles to reduce I/R injury. As far as currently known, similar molecular mechanisms mediate ischaemic and pharmacological preconditioning in the left and right ventricles. However, the two ventricles seem to respond differently towards exercise-induced preconditioning.

Harvard Citation style: Boengler, K., Schlueter, K., Schermuly, R. and Schulz, R. (2020) Cardioprotection in right heart failure, British Journal of Pharmacology, 177(23), pp. 5413-5431. https://doi.org/10.1111/bph.14992

APA Citation style: Boengler, K., Schlueter, K., Schermuly, R., & Schulz, R. (2020). Cardioprotection in right heart failure. British Journal of Pharmacology. 177(23), 5413-5431. https://doi.org/10.1111/bph.14992