Journalartikel
Autorenliste: Konrad, Lutz; Dietze, Raimund; Riaz, Muhammad A.; Scheiner-Bobis, Georgios; Behnke, Judith; Horne, Fabian; Hoerscher, Alena; Reising, Christoph; Meinhold-Heerlein, Ivo
Jahr der Veröffentlichung: 2020
Zeitschrift: Journal of Clinical Medicine
Bandnummer: 9
Heftnummer: 6
eISSN: 2077-0383
Open Access Status: Gold
DOI Link: https://doi.org/10.3390/jcm9061915
Verlag: MDPI
Abstract:
Epithelial-mesenchymal transition (EMT) is an important process of cell remodeling characterized by the gradual loss of the epithelial phenotype and progressive gain of a mesenchymal phenotype. EMT is not an all-or-nothing process, but instead a transition of epithelial to mesenchymal cells with intermediate cell states. Recently, EMT was described in endometriosis, and many EMT-specific pathways like Twist, Snail, Slug, Zinc finger E-box-binding homeobox 1/2 (ZEB1/2), E/N-cadherin, keratins, and claudins are involved. However, as pointed out in this review, a comparison of the eutopic endometrium of women with and without endometriosis yielded only subtle changes of these EMT markers. Furthermore, only very few alterations in cell-cell contacts could be found but without changes in the epithelial phenotype. This suggests only a partial EMT which is not a prerequisite for the detachment of endometrial cells and, thus, not critical for the first step(s) in the pathogenesis of endometriosis. In contrast, the majority of changes in the EMT-related marker expression were found in the ectopic endometrium, especially in the three endometriotic entities, ovarian, peritoneal, and deep infiltrating endometriosis (DIE), compared with the eutopic endometrium. In this review, we examine the most important EMT pathways described in endometriosis and propose that partial EMT might result from the interaction of endometrial implants with their surrounding microenvironment.
Zitierstile
Harvard-Zitierstil: Konrad, L., Dietze, R., Riaz, M., Scheiner-Bobis, G., Behnke, J., Horne, F., et al. (2020) Epithelial-Mesenchymal Transition in Endometriosis-When Does It Happen?, Journal of Clinical Medicine, 9(6), Article 1915. https://doi.org/10.3390/jcm9061915
APA-Zitierstil: Konrad, L., Dietze, R., Riaz, M., Scheiner-Bobis, G., Behnke, J., Horne, F., Hoerscher, A., Reising, C., & Meinhold-Heerlein, I. (2020). Epithelial-Mesenchymal Transition in Endometriosis-When Does It Happen?. Journal of Clinical Medicine. 9(6), Article 1915. https://doi.org/10.3390/jcm9061915
Schlagwörter
BETA-CATENIN; cell-cell contacts; ECTOPIC ENDOMETRIUM; Endometriosis; endometrium; EUTOPIC ENDOMETRIUM; METASTASIS; RETROGRADE MENSTRUATION
