Journal article

Publication year: 2020

Journal: Current Allergy and Asthma Reports

Volume number: 20

Issue number: 10

ISSN: 1529-7322

eISSN: 1534-6315

Open access status: Hybrid

DOI Link: https://doi.org/10.1007/s11882-020-00954-0

Publisher: Springer

Abstract: 
Purpose of ReviewStings of Hymenoptera of the superfamily Vespoidea such as yellow jackets, paper wasps or stinging ants are common triggers for severe and even fatal allergic reactions. Antigen 5 allergens are potent allergens in the majority of these venoms with major importance for diagnosis and therapy. Reviewed here are the characteristics of antigen 5 allergens, their role in component-resolved diagnostics as well as current limitations of the available diagnostics for proper therapeutic decisions.Recent FindingsAntigens 5 are proteins of unknown function in Hymenoptera venoms with high allergenic potency. They represent key elements in component-resolved diagnosis to discriminate between honeybee and vespid venom allergy. However, due to their pronounced cross-reactivity, there are remaining diagnostic and therapeutic challenges that have to be addressed.SummaryAntigens 5 are highly relevant venom allergens of the Vespoidea superfamily. Although their use in component-resolved diagnosis facilitates dissection of cross-reactivity and primary allergy in double sensitization to honeybee and vespid venom, new diagnostic concepts are needed to discriminate between allergies to different vespid species.

Harvard Citation style: Blank, S., Bazon, M., Grosch, J., Schmidt-Weber, C., Brochetto-Braga, M., Bilo, M., et al. (2020) Antigen 5 Allergens of Hymenoptera Venoms and Their Role in Diagnosis and Therapy of Venom Allergy, Current Allergy and Asthma Reports, 20(10), Article 58. https://doi.org/10.1007/s11882-020-00954-0

APA Citation style: Blank, S., Bazon, M., Grosch, J., Schmidt-Weber, C., Brochetto-Braga, M., Bilo, M., & Jakob, T. (2020). Antigen 5 Allergens of Hymenoptera Venoms and Their Role in Diagnosis and Therapy of Venom Allergy. Current Allergy and Asthma Reports. 20(10), Article 58. https://doi.org/10.1007/s11882-020-00954-0