Journal article
Authors list: Keranov, Stanislav; Doerr, Oliver; Jafari, Leili; Liebetrau, Christoph; Keller, Till; Troidl, Christian; Kriechbaum, Steffen; Voss, Sandra; Richter, Manuel; Tello, Khodr; Gall, Henning; Ghofrani, Hossein A.; Mayer, Eckhard; Seeger, Werner; Hamm, Christian W.; Nef, Holger
Publication year: 2020
Pages: 290-295
Journal: Biomarkers
Volume number: 25
Issue number: 3
ISSN: 1354-750X
eISSN: 1366-5804
Open access status: Green
DOI Link: https://doi.org/10.1080/1354750X.2020.1745889
Publisher: Taylor and Francis Group
Abstract:
Aim: This study assessed the utility of SPARC-like protein 1 (SPARCL1) as a biomarker of maladaptive right ventricular (RV) function in patients with pulmonary hypertension (PH). Methods: In this prospective study, we examined SPARCL1 levels in 105 patients with adaptive (n = 34) and maladaptive RV (n = 32) pressure overload caused by PH, dilated cardiomyopathy (DCM, n = 18) with LVEF < 35% and preserved RV function and controls without LV or RV abnormalities (n = 21). Results: The median SPARCL1 concentration in patients with maladaptive RV function was higher than in those with adaptive RV function (p < 0.01), DCM (p < 0.001) or controls (p < 0.001). Patients with adaptive RV function had higher SPARCL1 concentrations than controls (p < 0.05), whereas there was no difference between adaptive RV and DCM. SPARCL1 showed good predictive power for maladaptive RV (AUC 0.77, p < 0.001) with an optimal cut-off value of 9.66 ng/ml. The TAPSE/PASP ratio was the only independent predictor of SPARCL1 >= 9.66 ng/ml in multivariable logistic regression analysis. Conclusion: SPARCL1 shows potential as novel biomarker of RV pathological remodelling and is associated with RV maladaptation and ventriculoarterial uncoupling in PH.
Citation Styles
Harvard Citation style: Keranov, S., Doerr, O., Jafari, L., Liebetrau, C., Keller, T., Troidl, C., et al. (2020) SPARCL1 as a biomarker of maladaptive right ventricular remodelling in pulmonary hypertension, Biomarkers, 25(3), pp. 290-295. https://doi.org/10.1080/1354750X.2020.1745889
APA Citation style: Keranov, S., Doerr, O., Jafari, L., Liebetrau, C., Keller, T., Troidl, C., Kriechbaum, S., Voss, S., Richter, M., Tello, K., Gall, H., Ghofrani, H., Mayer, E., Seeger, W., Hamm, C., & Nef, H. (2020). SPARCL1 as a biomarker of maladaptive right ventricular remodelling in pulmonary hypertension. Biomarkers. 25(3), 290-295. https://doi.org/10.1080/1354750X.2020.1745889
Keywords
adaptive and maladaptive right ventricular pressure overload; cardiac remodelling; CIRCULATION; CONTRACTILE FUNCTION; HEART-FAILURE; MATRICELLULAR PROTEINS; PASP; SPARCL1; TAPSE; ventriculoarterial uncoupling pulmonary hypertension
