Journalartikel
Autorenliste: von Spreckelsen, Niklas; Waldt, Natalie; Poetschke, Rebecca; Kesseler, Christoph; Dohmen, Hildegard; Jiao, Hui-Ke; Nemeth, Attila; Schob, Stefan; Scherlach, Cordula; Sandalcioglu, Ibrahim Erol; Deckert, Martina; Angenstein, Frank; Krischek, Boris; Stavrinou, Pantelis; Timmer, Marco; Remke, Marc; Kirches, Elmar; Goldbrunner, Roland; Chiocca, E. Antonio; Huettelmaier, Stefan; Acker, Till; Mawrin, Christian
Jahr der Veröffentlichung: 2020
Zeitschrift: Acta Neuropathologica Communications
Bandnummer: 8
Heftnummer: 1
ISSN: 2051-5960
Open Access Status: Gold
DOI Link: https://doi.org/10.1186/s40478-020-00912-x
Verlag: BioMed Central
Abstract:
Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical observations. Alterations of cellular pathways due to these mutations, however, have largely remained elusive. Here we report that the Krueppel like factor 4 (KLF4)-K409Q mutation in skull base meningiomas triggers a distinct tumor phenotype. Transcriptomic analysis of 17 meningioma samples revealed that KLF4(K409Q) mutated tumors harbor an upregulation of hypoxia dependent pathways. Detailed in vitro investigation further showed that the KLF4(K409Q) mutation induces HIF-1 alpha through the reduction of prolyl hydroxylase activity and causes an upregulation of downstream HIF-1 alpha targets. Finally, we demonstrate that KLF4(K409Q) mutated tumors are susceptible to mTOR inhibition by Temsirolimus. Taken together, our data link the KLF4(K409Q) mediated upregulation of HIF pathways to the clinical and biological characteristics of these skull base meningiomas possibly opening new therapeutic avenues for this distinct meningioma subtype.
Zitierstile
Harvard-Zitierstil: von Spreckelsen, N., Waldt, N., Poetschke, R., Kesseler, C., Dohmen, H., Jiao, H., et al. (2020) KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment, Acta Neuropathologica Communications, 8(1), Article 41. https://doi.org/10.1186/s40478-020-00912-x
APA-Zitierstil: von Spreckelsen, N., Waldt, N., Poetschke, R., Kesseler, C., Dohmen, H., Jiao, H., Nemeth, A., Schob, S., Scherlach, C., Sandalcioglu, I., Deckert, M., Angenstein, F., Krischek, B., Stavrinou, P., Timmer, M., Remke, M., Kirches, E., Goldbrunner, R., Chiocca, E., ...Mawrin, C. (2020). KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment. Acta Neuropathologica Communications. 8(1), Article 41. https://doi.org/10.1186/s40478-020-00912-x
Schlagwörter
Edema; ENDOTHELIAL GROWTH-FACTOR; HIF; K409Q; KLF4; Meningioma; PERITUMORAL BRAIN EDEMA; SECRETORY MENINGIOMAS; SKULL BASE MENINGIOMAS; TUMOR-SUPPRESSOR
