Journal article

Publication year: 2020

Pages: 144-147

Journal: International Journal of Cardiology

Volume number: 304

ISSN: 0167-5273

eISSN: 1874-1754

DOI Link: https://doi.org/10.1016/j.ijcard.2020.01.043

Publisher: Elsevier

Abstract: 

Myocardial infarction (MI) not only defines acute MI with obstructed coronary arteries (T1MI) but also myocardial necrosis caused by myocardial oxygen supply/demand mismatch as type 2 MI (T2MI); only T1MI patients benefit from an early invasive management. Myeloid-related protein(MRP)-8/14 is a biomarker described in various inflammatory diseases and in MI patients. Here we evaluate the potential of MRP-8/14 and high-sensitivity troponin I (hs-cTnI) to differentiate T2MI from T1MI.

Patients with final diagnosis NSTEMI (n = 254; 33.1% female) enrolled in a prospective biomarker registry between 08/2011 and 10/2016 were analysed. Median baseline MRP-8/14 levels were higher in T2MI (n = 55; 3.37(1.88-6.48)mu g/mL) than in T1MI ( n = 199; 2.4 [1.4-3.79]mu g/mL) (p = .013) patients, in contrast to hs-cTnI (T2MI:52[11.65-321.4]ng/L vs. T1MI:436.5 [61.25-1973.8]ng/L; p < .001). To detect the strength of this association odds ratios(OR) were calculated with MRP-8/14 yielding 2.13 (1.16-3.92; p = .015) to predict T2MI and 0.47(0.26-0.87; p = .015) for T1MI. As expected, hs-cTnI yielded an OR of to predict T2MI 0.34(0.17-0.65; p = .001) and 2.98(1.53-5.81; p = .001) for T1MI. Both markers show comparable and independent results if adjust to hs-cTnI/MRP-8/14, TIMI risk score and CRP.

T2MI is associated with higher MRP-8/14 and lower hs-cTnI concentrations than T1MI. Our data suggest that MRP-8/14 as a marker of inflammation might provide usable discriminatory information complementing hs-cTnI in a diagnostic procedure evaluating the type of MI directly upon hospital admission. (C) 2020 Elsevier B.V. All rights reserved.

Harvard Citation style: Bormann, J., Psyrakis, D., von Jeinsen, B., Gruen, D., Elsner, L., Wolter, J., et al. (2020) Myeloid-related protein 8/14 and high-sensitivity cardiac troponin I to differentiate type 2 myocardial infarction, International Journal of Cardiology, 304, pp. 144-147. https://doi.org/10.1016/j.ijcard.2020.01.043

APA Citation style: Bormann, J., Psyrakis, D., von Jeinsen, B., Gruen, D., Elsner, L., Wolter, J., Weferling, M., Diouf, K., Kriechbaum, S., Troidl, C., Doerr, O., Nef, H., Hamm, C., Liebetrau, C., & Keller, T. (2020). Myeloid-related protein 8/14 and high-sensitivity cardiac troponin I to differentiate type 2 myocardial infarction. International Journal of Cardiology. 304, 144-147. https://doi.org/10.1016/j.ijcard.2020.01.043