Journalartikel
Autorenliste: Pergande, Matthias; Motameny, Susanne; Oezdemir, Oezkan; Kreutzer, Mona; Wang, Haicui; Daimagueler, Huelya-Sevcan; Becker, Kerstin; Karakaya, Mert; Ehrhardt, Harald; Elcioglu, Nursel; Ostojic, Slavica; Chao, Cho-Ming; Kawalia, Amit; Duman, Ozgur; Koy, Anne; Hahn, Andreas; Reimann, Jens; Schoner, Katharina; Schaenzer, Anne; Westhoff, Jens H.; Schwaibold, Eva Maria Christina; Cossee, Mireille; Imbert-Bouteille, Marion; von Pein, Harald; Haliloglu, Goknur; Topaloglu, Haluk; Altmueller, Janine; Nuernberg, Peter; Thiele, Holger; Heller, Raoul; Cirak, Sebahattin
Jahr der Veröffentlichung: 2020
Seiten: 511-523
Zeitschrift: Genetics in Medicine
Bandnummer: 22
Heftnummer: 3
ISSN: 1098-3600
eISSN: 1530-0366
Open Access Status: Green
DOI Link: https://doi.org/10.1038/s41436-019-0680-1
Verlag: Elsevier
Abstract:
Purpose Fetal akinesia has multiple clinical subtypes with over 160 gene associations, but the genetic etiology is not yet completely understood. Methods In this study, 51 patients from 47 unrelated families were analyzed using next-generation sequencing (NGS) techniques aiming to decipher the genomic landscape of fetal akinesia (FA). Results We have identified likely pathogenic gene variants in 37 cases and report 41 novel variants. Additionally, we report putative pathogenic variants in eight cases including nine novel variants. Our work identified 14 novel disease-gene associations for fetal akinesia: ADSSL1, ASAH1, ASPM, ATP2B3, EARS2, FBLN1, PRG4, PRICKLE1, ROR2, SETBP1, SCN5A, SCN8A, and ZEB2. Furthermore, a sibling pair harbored a homozygous copy-number variant in TNNT1, an ultrarare congenital myopathy gene that has been linked to arthrogryposis via Gene Ontology analysis. Conclusion Our analysis indicates that genetic defects leading to primary skeletal muscle diseases might have been underdiagnosed, especially pathogenic variants in RYR1. We discuss three novel putative fetal akinesia genes: GCN1, IQSEC3 and RYR3. Of those, IQSEC3, and RYR3 had been proposed as neuromuscular disease-associated genes recently, and our findings endorse them as FA candidate genes. By combining NGS with deep clinical phenotyping, we achieved a 73% success rate of solved cases.
Zitierstile
Harvard-Zitierstil: Pergande, M., Motameny, S., Oezdemir, O., Kreutzer, M., Wang, H., Daimagueler, H., et al. (2020) The genomic and clinical landscape of fetal akinesia, Genetics in Medicine, 22(3), pp. 511-523. https://doi.org/10.1038/s41436-019-0680-1
APA-Zitierstil: Pergande, M., Motameny, S., Oezdemir, O., Kreutzer, M., Wang, H., Daimagueler, H., Becker, K., Karakaya, M., Ehrhardt, H., Elcioglu, N., Ostojic, S., Chao, C., Kawalia, A., Duman, O., Koy, A., Hahn, A., Reimann, J., Schoner, K., Schaenzer, A., ...Cirak, S. (2020). The genomic and clinical landscape of fetal akinesia. Genetics in Medicine. 22(3), 511-523. https://doi.org/10.1038/s41436-019-0680-1
Schlagwörter
arthrogryposis; COPY-NUMBER VARIATION; DISTAL ARTHROGRYPOSIS; Exome; fetal akinesia; myopathy; nemaline myopathy; VARIANTS
