Journal article

Identification of the general stress stimulon related to colonization in Enterococcus faecalis


Authors listSalze, Marine; Giard, Jean-Christophe; Riboulet-Bisson, Eliette; Hain, Torsten; Rince, Alain; Muller, Cecile

Publication year2020

Pages233-246

JournalArchives of Microbiology

Volume number202

Issue number2

ISSN0302-8933

eISSN1432-072X

DOI Linkhttps://doi.org/10.1007/s00203-019-01735-8

PublisherSpringer


Abstract
Enterococcus faecalis has to cope with major stress conditions during colonization. To understand the effects of stress encountered during infection, the present study assessed the transcriptomic response of the bacteria facing exposure to serum, urine, bile salts, acid pH, or oxidative stress. Compared to non-stressed culture, 30% of the E. faecalis genes were differentially expressed. The transcriptome analysis reveals common but also specific responses, depending on stresses encountered: thus, urine exposure has the most important impact, and the highest number of genes with modified expression is involved in transport and metabolism. The results also pinpoint many stress-related sRNA or intergenic regions not yet characterized. This study identified the general stress stimulon related to infection: when the commensal bacterium initiates its response to stress related to infection, it increases its ability to survive to rough conditions for colonization, rather than promoting expression of virulence factors, and becomes this opportunistic pathogen that thrives in hospital settings.



Citation Styles

Harvard Citation styleSalze, M., Giard, J., Riboulet-Bisson, E., Hain, T., Rince, A. and Muller, C. (2020) Identification of the general stress stimulon related to colonization in Enterococcus faecalis, Archives of Microbiology, 202(2), pp. 233-246. https://doi.org/10.1007/s00203-019-01735-8

APA Citation styleSalze, M., Giard, J., Riboulet-Bisson, E., Hain, T., Rince, A., & Muller, C. (2020). Identification of the general stress stimulon related to colonization in Enterococcus faecalis. Archives of Microbiology. 202(2), 233-246. https://doi.org/10.1007/s00203-019-01735-8



Keywords


BILEPHYSIOLOGICAL ROLES

Last updated on 2025-21-05 at 18:23