Journal article

Publication year: 2020

Pages: 751-759

Journal: British Journal of Haematology

Volume number: 189

Issue number: 4

ISSN: 0007-1048

eISSN: 1365-2141

Open access status: Hybrid

DOI Link: https://doi.org/10.1111/bjh.16419

Publisher: Wiley

Abstract: 
The causative role of maternal, anti-human leukocyte antigen (anti-HLA) class I antibodies in foetal and neonatal alloimmune thrombocytopenia (FNAIT) remains controversial. Furthermore, in FNAIT cases caused by anti-human platelet antigen-1a (anti-HPA-1a) antibodies, the possible additive effect of maternal anti-HLA class I antibodies on outcomes is unclear. Among 817 mother-father-neonate trios of suspected FNAIT, we assessed the possible association of maternal anti-HLA class I antibodies with neonatal platelet count, and the incidence of FNAIT caused by anti-HPA-1a antibodies. In 144 FNAIT cases caused by anti-HPA-1a antibodies, we investigated the possible association of maternal anti-HLA class I antibodies with neonatal platelet count, birth weight, and the incidence of intracranial haemorrhage (n = 16). Maternal anti-HLA class I antibodies were not associated with neonatal platelet count in suspected cases of FNAIT. There was no significant interaction between the presence of anti-HLA class I antibodies and anti-HPA-1a antibodies. In FNAIT cases caused by anti-HPA-1a antibodies, there was no association between the presence of anti-HLA class I antibodies and neonatal platelet count, birth weight, or occurrence of intracranial haemorrhage. This study's findings do not support the concept that maternal anti-HLA class I antibodies represent a risk factor of FNAIT or disease severity.

Harvard Citation style: Sachs, U., Wienzek-Lischka, S., Duong, Y., Qiu, D., Hinrichs, W., Cooper, N., et al. (2020) Maternal antibodies against paternal class I human leukocyte antigens are not associated with foetal and neonatal alloimmune thrombocytopenia, British Journal of Haematology, 189(4), pp. 751-759. https://doi.org/10.1111/bjh.16419

APA Citation style: Sachs, U., Wienzek-Lischka, S., Duong, Y., Qiu, D., Hinrichs, W., Cooper, N., Santoso, S., Bayat, B., & Bein, G. (2020). Maternal antibodies against paternal class I human leukocyte antigens are not associated with foetal and neonatal alloimmune thrombocytopenia. British Journal of Haematology. 189(4), 751-759. https://doi.org/10.1111/bjh.16419