Journal article

Publication year: 2019

Journal: The Journal of Steroid Biochemistry and Molecular Biology

Volume number: 194

ISSN: 0960-0760

DOI Link: https://doi.org/10.1016/j.jsbmb.2019.105438

Publisher: Elsevier

Abstract: 
The metabolism of drugs in mammals is attributed mainly to the liver and its cytochromes P450 localized in the endoplasmic reticulum. Here, we demonstrate for the first time in humans that there is no strict subdivision between P450 s involved in exogenous and endogenous metabolism. We determined the widely used mineralocorticoid receptor antagonist spironolactone, its active metabolite canrenone and their metabolites in the adrenal venous blood of treated patients with gas chromatography-mass spectrometry. 11- and 18-hydroxylated metabolites of canrenone were found in the efferent right and left adrenal veins, indicating that they were produced by the adrenal mitochondrial cytochromes P450 CYP11B1 and CYP11B2. Thus, the adrenal has to be considered as a new organ for drug metabolism. In future, application of drugs may need further investigations concerning side effects due to interactions with adrenal enzymes.

Harvard Citation style: Hartmann, M., Reincke, M., Wudy, S. and Bernhardt, R. (2019) The human adrenal gland as a drug metabolizer: First in-vivo evidence for the conversion of steroidal drugs, The Journal of Steroid Biochemistry and Molecular Biology, 194, Article 105438. https://doi.org/10.1016/j.jsbmb.2019.105438

APA Citation style: Hartmann, M., Reincke, M., Wudy, S., & Bernhardt, R. (2019). The human adrenal gland as a drug metabolizer: First in-vivo evidence for the conversion of steroidal drugs. The Journal of Steroid Biochemistry and Molecular Biology. 194, Article 105438. https://doi.org/10.1016/j.jsbmb.2019.105438