Journal article

Publication year: 2020

Pages: 277-284

Journal: Current Medical Research and Opinion

Volume number: 36

Issue number: 2

ISSN: 0300-7995

eISSN: 1473-4877

DOI Link: https://doi.org/10.1080/03007995.2019.1681133

Publisher: Taylor and Francis Group

Abstract: 
Objective: To evaluate the real-life effectiveness, safety, tolerability and patient-reported outcomes (PRO) of the sufentanil sublingual tablet system (SSTS) for postoperative pain management (POPM). Methods: This prospective, multicenter, noninterventional, study included adults with acute moderate to severe postoperative pain who self-administered sufentanil using the SSTS. Main outcome measures were pain intensity at rest (numerical rating scale [NRS]: 0 [no pain] to 10 [most intense pain imaginable]); most intense pain intensity (0-10); 4-point patient assessment of the pain control method ("excellent", "good", "fair", "poor"); patient satisfaction with the pain control level and the method of administration of pain medication (6-point scale: "extremely satisfied", "very satisfied", "satisfied", "dissatisfied", "very dissatisfied", "extremely dissatisfied"). Adverse drug reactions were recorded. Results: The SSTS reduced resting pain intensity in patients (n = 341) from a mean +/- SD NRS score of 5.2 +/- 2.3 (at SSTS handover) to 1.8 +/- 1.6 (3rd day after handover). The proportion of patients with severe pain (for the PRO measure "most intense pain") decreased steadily during the 72 hours of treatment. Overall, 87.1% of the patients reported the method of pain control to be "good" or "excellent"; 91.8% reported being "extremely/very satisfied" or "satisfied" with the level of pain control; and 95.9% were at least satisfied with the method of pain medication administration. SSTS safety and tolerability was typical for opioids and as described in the SSTS Summary of Product Characteristics. Conclusions: The SSTS is a valuable option for real-life POPM and is effective in a wide range of surgical procedures.

Harvard Citation style: Pogatzki-Zahn, E., Kranke, P., Winner, J., Weyland, W., Reich, A., Vigelius-Rauch, U., et al. (2020) Real-world use of the sufentanil sublingual tablet system for patient-controlled management of acute postoperative pain: a prospective noninterventional study, Current Medical Research and Opinion, 36(2), pp. 277-284. https://doi.org/10.1080/03007995.2019.1681133

APA Citation style: Pogatzki-Zahn, E., Kranke, P., Winner, J., Weyland, W., Reich, A., Vigelius-Rauch, U., Paland, M., Loehr, T., & Eberhar, L. (2020). Real-world use of the sufentanil sublingual tablet system for patient-controlled management of acute postoperative pain: a prospective noninterventional study. Current Medical Research and Opinion. 36(2), 277-284. https://doi.org/10.1080/03007995.2019.1681133