Journal article

Publication year: 2019

Pages: 509-516

Journal: Herz: Cardiovascular Diseases

Volume number: 44

Issue number: 6

ISSN: 0340-9937

eISSN: 1615-6692

DOI Link: https://doi.org/10.1007/s00059-019-4815-6

Publisher: Springer

Abstract: 
The right ventricle (RV) is the main determinant of prognosis in pulmonary hypertension. Adaptation and maladaptation of the RV are of crucial importance. In the course of disease, RV contractility increases through changes in muscle properties and muscle hypertrophy. At a certain point, the point of "uncoupling," the afterload exceeds contractility, and maladaptation as well as dilation occurs to maintain stroke volume (SV). To understand the adaptational processes and to further develop targeted medication directly affecting load-independent contractility, an accurate and precise assessment of contractility and RV-pulmonary artery (PA) coupling should be performed. In this review, we shed light on existing methods to assess RV function, including the gold standard measurement of contractility and RV-PA coupling, and we evaluate existing surrogates of RV-PA coupling.

Harvard Citation style: Tello, K., Gall, H., Richter, M., Ghofrani, A. and Schermuly, R. (2019) Right ventricular function in pulmonary (arterial) hypertension, Herz: Cardiovascular Diseases, 44(6), pp. 509-516. https://doi.org/10.1007/s00059-019-4815-6

APA Citation style: Tello, K., Gall, H., Richter, M., Ghofrani, A., & Schermuly, R. (2019). Right ventricular function in pulmonary (arterial) hypertension. Herz: Cardiovascular Diseases. 44(6), 509-516. https://doi.org/10.1007/s00059-019-4815-6