Journal article

Publication year: 2019

Pages: 3869-3879

Journal: Head and Neck

Volume number: 41

Issue number: 11

ISSN: 1043-3074

eISSN: 1097-0347

Open access status: Hybrid

DOI Link: https://doi.org/10.1002/hed.25924

Publisher: Wiley

Abstract: 
Background It was tested whether the difference in carcinogenesis between noxa and human papillomavirus (HPV)-driven head and neck squamous cell carcinoma (HNSCC) is associated with a variation in genomic instability. Methods Conventional and molecular cytogenetics in HPV-positive and HPV-negative HNSCC cell lines. Results Numerical aneuploidy determined by multicolor fluorescence in situ hybridization and DNA ploidy was very similar for both entities with most chromosomes being present either in quadruplicate or triplicate, and only few are still diploid with, however, a striking similarity in the overall pattern. A clear difference was seen concerning the translocations formed, with no difference in the total amount but with a significantly higher genomic instability of HPV-positive cell lines at chromosome 3 as compared to HPV-negative cells. Conclusion The different processes of carcinogenesis of HPV-positive and HPV-negative HNSCC appear to result in a similar pattern of numerical but a clear difference in structural chromosomal aberrations.

Harvard Citation style: Arenz, A., Patze, J., Kornmann, E., Wilhelm, J., Ziemann, F., Wagner, S., et al. (2019) HPV-negative and HPV-positive HNSCC cell lines show similar numerical but different structural chromosomal aberrations, Head and Neck, 41(11), pp. 3869-3879. https://doi.org/10.1002/hed.25924

APA Citation style: Arenz, A., Patze, J., Kornmann, E., Wilhelm, J., Ziemann, F., Wagner, S., Wittig, A., Schoetz, U., Engenhart-Cabillic, R., Dikomey, E., & Fritz, B. (2019). HPV-negative and HPV-positive HNSCC cell lines show similar numerical but different structural chromosomal aberrations. Head and Neck. 41(11), 3869-3879. https://doi.org/10.1002/hed.25924