Journal article

Publication year: 2019

Pages: 601-613

Journal: Archives of Gynecology and Obstetrics

Volume number: 300

Issue number: 3

ISSN: 0932-0067

eISSN: 1432-0711

DOI Link: https://doi.org/10.1007/s00404-019-05198-6

Publisher: Springer

Abstract: 
Purpose Birth weight (BW) is crucial for surgical outcome in children with left heart obstruction (LHO). Head circumference (HC) is believed to correlate with the neurocognitive outcome in LHO. Our aim was to investigate the application of international standardized growth charts from the INTERGROWTH-21st project in comparison to customized growth charts in fetal LHO. Methods This is a retrospective cohort study consisting of 60 singleton pregnancies complicated by fetal LHO. For the z score calculation of estimated fetal weight (EFW) and biometric parameters, the INTERGROWTH-21st calculator was used as well as algorithms of customized growth charts. Antenatal measurements were compared to newborn biometry and the association with fetal Doppler results (MCA PI: middle cerebral artery pulsatility index and CPR: cerebroplacental ratio) was examined. Furthermore, the ability of each antenatal chart to predict adverse perinatal outcome was evaluated. Results At a mean gestational age of 37 weeks, all assessment charts showed significantly smaller mean values for antenatal head circumference (HC) z scores. Highest detection rate for restricted HC growth antenatally was achieved with Hadlock charts. MCA PI and CPR were not associated with neonatal HC. A significant association was observed between EFW and 1-year survival, independent of the considered growth chart. Conclusions Growth chart independently, antenatal HC did tend to be smaller in LHO fetuses. A significant association was observed between EFW and 1-year survival rate. Prospective investigations in CHD fetuses should be carried out with internationally standardized growth charts to better examine their prognostic value in this high-risk population.

Harvard Citation style: Graupner, O., Helfrich, F., Ostermayer, E., Lobmaier, S., Ortiz, J., Ewert, P., et al. (2019) Application of the INTERGROWTH-21st chart compared to customized growth charts in fetuses with left heart obstruction: late trimester biometry, cerebroplacental hemodynamics and perinatal outcome, Archives of Gynecology and Obstetrics, 300(3), pp. 601-613. https://doi.org/10.1007/s00404-019-05198-6

APA Citation style: Graupner, O., Helfrich, F., Ostermayer, E., Lobmaier, S., Ortiz, J., Ewert, P., Wacker-Gussmann, A., Haller, B., Axt-Fliedner, R., Enzensberger, C., Abel, K., Karge, A., Oberhofferz, R., & Kuschel, B. (2019). Application of the INTERGROWTH-21st chart compared to customized growth charts in fetuses with left heart obstruction: late trimester biometry, cerebroplacental hemodynamics and perinatal outcome. Archives of Gynecology and Obstetrics. 300(3), 601-613. https://doi.org/10.1007/s00404-019-05198-6