Journal article

Publication year: 2019

Journal: Translational Vision Science & Technology

Volume number: 8

Issue number: 3

ISSN: 2164-2591

Open access status: Gold

DOI Link: https://doi.org/10.1167/tvst.8.3.62

Publisher: Association for Research in Vision and Ophthalmology

Abstract: 

Purpose: We correlate dark adaptation course with foveal morphologic alterations in preterm and term-born children using a modified fundus-controlled perimeter and spectral domain-optical coherence tomography (SD-OCT) imaging.

Methods: We performed fundus-controlled chromatic dark adaptometry in premature children aged 6 to 13 years without retinopathy of prematurity (no-ROP; n = 61) and with spontaneously regressed ROP (sr-ROP, n = 29), and in 11 age-matched term-born children. The degree of macular developmental arrest (MDA), defined as a disproportion of the outer nuclear layer to inner retinal layers in the fovea (ONL+/ IRL-ratio), was analyzed with the DiOCTA tool in SD-OCT scans.

Results: Children with MDA showed a flatter dark adaptation course progression with a significant rod-mediated sensitivity recovery delay (0.0113 vs. 0.0253 dB/s; P, 0.001). Preterm-born children with regular foveal morphology reached the final rodmediated dark-adapted threshold at 12 minutes after bleach at 18.8 dB, compared to after 18.7 minutes at 17.6 dB in children with MDA (no significant difference in final threshold; P = 0.773). The cone-mediated dark adaptation progression showed a significant lower final threshold in children with MDA (6.0 vs. 8.1 dB; P = 0.004).

Conclusions: Changes in dark adaptation were seen in the presence of MDA observed in premature children in the no-ROP and sr-ROP groups. MDA in former premature children is associated with functional deficits of cone and rod photoreceptor visual pathways.

Harvard Citation style: Bowl, W., Lorenz, B., Stieger, K., Schweinfurth, S., Holve, K. and Andrassi-Darida, M. (2019) Fundus-Controlled Dark Adaptometry in Young Children Without and With Spontaneously Regressed Retinopathy of Prematurity, Translational Vision Science & Technology, 8(3), Article 62. https://doi.org/10.1167/tvst.8.3.62

APA Citation style: Bowl, W., Lorenz, B., Stieger, K., Schweinfurth, S., Holve, K., & Andrassi-Darida, M. (2019). Fundus-Controlled Dark Adaptometry in Young Children Without and With Spontaneously Regressed Retinopathy of Prematurity. Translational Vision Science & Technology. 8(3), Article 62. https://doi.org/10.1167/tvst.8.3.62