Journal article
Authors list: Shehata, Mahmoud M.; Mostafa, Ahmed; Teubner, Lisa; Mahmoud, Sara H.; Kandeil, Ahmed; Elshesheny, Rabeh; Boubak, Thamer A.; Frantz, Renate; La Pietra, Luigi; Pleschka, Stephan; Osman, Ahmed; Kayali, Ghazi; Chakraborty, Trinad; Ali, Mohamed A.; Abu Mraheil, Mobarak
Publication year: 2019
Journal: Vaccines
Volume number: 7
Issue number: 2
eISSN: 2076-393X
Open access status: Gold
DOI Link: https://doi.org/10.3390/vaccines7020046
Publisher: MDPI
Abstract:
Vaccination is the most functional medical intervention to prophylactically control severe diseases caused by human-to-human or animal-to-human transmissible viral pathogens. Annually, seasonal influenza epidemics attack human populations leading to 290-650 thousand deaths/year worldwide. Recently, a novel Middle East Respiratory Syndrome Coronavirus emerged. Together, those two viruses present a significant public health burden in areas where they circulate. Herein, we generated a bacterial outer membrane vesicles (OMVs)-based vaccine presenting the antigenic stable chimeric fusion protein of the H1-type haemagglutinin (HA) of the pandemic influenza A virus (H1N1) strain from 2009 (H1N1pdm09) and the receptor binding domain (RBD) of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (OMVs-H1/RBD). Our results showed that the chimeric antigen could induce specific neutralizing antibodies against both strains leading to protection of immunized mice against H1N1pdm09 and efficient neutralization of MERS-CoV. This study demonstrate that OMVs-based vaccines presenting viral antigens provide a safe and reliable approach to protect against two different viral infections.
Citation Styles
Harvard Citation style: Shehata, M., Mostafa, A., Teubner, L., Mahmoud, S., Kandeil, A., Elshesheny, R., et al. (2019) Bacterial Outer Membrane Vesicles (OMVs)-Based Dual Vaccine for Influenza A H1N1 Virus and MERS-CoV, Vaccines, 7(2), Article 46. https://doi.org/10.3390/vaccines7020046
APA Citation style: Shehata, M., Mostafa, A., Teubner, L., Mahmoud, S., Kandeil, A., Elshesheny, R., Boubak, T., Frantz, R., La Pietra, L., Pleschka, S., Osman, A., Kayali, G., Chakraborty, T., Ali, M., & Abu Mraheil, M. (2019). Bacterial Outer Membrane Vesicles (OMVs)-Based Dual Vaccine for Influenza A H1N1 Virus and MERS-CoV. Vaccines. 7(2), Article 46. https://doi.org/10.3390/vaccines7020046
Keywords
H1N1pdm; IMMUNOGENICITY; INFLUENZA VACCINE; MERS-CoV; OMVs; PROTECT; RECEPTOR-BINDING DOMAIN
