Journalartikel

Jahr der Veröffentlichung: 2019

Seiten: 2250-2256

Zeitschrift: The Journal of Clinical Endocrinology & Metabolism

Bandnummer: 104

Heftnummer: 6

ISSN: 0021-972X

eISSN: 1945-7197

Open Access Status: Bronze

DOI Link: https://doi.org/10.1210/jc.2018-02108

Verlag: Oxford University Press

Abstract: 

Context: Elevated bone marrow adipose tissue (BMAT) is associated with lower bone quality, higher fracture rates, and an unfavorable overall metabolic profile. Apart from age, particularly gluco-corticoids (GC), body fat, and diet are discussed to influence BMAT. We hypothesized that already in healthy youths, higher fat intake, higher fat mass index (FMI), and higher GC secretion, still within the normal range, may associate with increased BMAT.

Design: In a subsample of healthy 6- to 18-year-old participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed Study, peripheral quantitative CT of the nondominant proximal forearm was used to determine bone marrow density of the distal radius as an inverse surrogate parameter for BMAT. In those participants (n = 172) who had collected two, 24-hour urines within around one year before bone measurement, major urinary GC metabolites were measured by gas chromatography-mass spectrometry and summed up to assess daily adrenal GC secretion (Sigma C21). Dietary intake was assessed by 3-day weighed dietary records. FMI was anthropometrically calculated. Separate multiple linear regression models were used to analyze the relationships of Sigma C21, FMI, and fat intake with BMAT.

Results: After controlling for confounders, such as age, energy intake, and forearm muscle area, Sigma C21 (beta= -0.042) and FMI (beta = -0.002) showed inverse relationships with bone marrow density (P < 0.05), whereas fat intake did not associate significantly.

Conclusion: Our results indicate that already a moderately elevated GC secretion and higher body fatness during adolescence may adversely impact BMAT, an indicator for long-term bone health.

Harvard-Zitierstil: Esche, J., Shi, L., Hartmann, M., Schoenau, E., Wudy, S. and Remer, T. (2019) Glucocorticoids and Body Fat Inversely Associate With Bone Marrow Density of the Distal Radius in Healthy Youths, The Journal of Clinical Endocrinology & Metabolism, 104(6), pp. 2250-2256. https://doi.org/10.1210/jc.2018-02108

APA-Zitierstil: Esche, J., Shi, L., Hartmann, M., Schoenau, E., Wudy, S., & Remer, T. (2019). Glucocorticoids and Body Fat Inversely Associate With Bone Marrow Density of the Distal Radius in Healthy Youths. The Journal of Clinical Endocrinology & Metabolism. 104(6), 2250-2256. https://doi.org/10.1210/jc.2018-02108