Journal article
Authors list: Boengler, Kerstin; Bornbaum, Julia; Schlueter, Klaus-Dieter; Schulz, Rainer
Publication year: 2019
Journal: Basic Research in Cardiology
Volume number: 114
Issue number: 4
ISSN: 0300-8428
eISSN: 1435-1803
DOI Link: https://doi.org/10.1007/s00395-019-0738-x
Publisher: Springer
Abstract:
Oxidative stress caused by an imbalance in the formation and removal of reactive oxygen species (ROS) plays an important role in the development of several cardiovascular diseases. ROS originate from various cellular origins; however, the highest amount of ROS is produced by mitochondria. One of the proteins contributing to mitochondrial ROS formation is the adaptor protein p66shc, which upon cellular stresses translocates from the cytosol to the mitochondria. In the present review, we focus on the role of p66shc in longevity, in the development of cardiovascular diseases including diabetes, atherosclerosis and its risk factors, myocardial ischemia/reperfusion injury and the protection from it by ischemic preconditioning. Also, the contribution of p66shc towards cerebral pathologies and the potential of the protein as a therapeutic target for the treatment of the aforementioned diseases are discussed.
Citation Styles
Harvard Citation style: Boengler, K., Bornbaum, J., Schlueter, K. and Schulz, R. (2019) P66shc and its role in ischemic cardiovascular diseases, Basic Research in Cardiology, 114(4), Article 29. https://doi.org/10.1007/s00395-019-0738-x
APA Citation style: Boengler, K., Bornbaum, J., Schlueter, K., & Schulz, R. (2019). P66shc and its role in ischemic cardiovascular diseases. Basic Research in Cardiology. 114(4), Article 29. https://doi.org/10.1007/s00395-019-0738-x
Keywords
ADAPTER PROTEIN; FREE-RADICALS; ISCHEMIA/REPERFUSION INJURY; KINASE-C-BETA; p66Shc; P66(SHC) LONGEVITY GENE; PERIPHERAL-BLOOD MONOCYTES; preconditioning; reperfusion
