Journalartikel
Autorenliste: Yuan, Tingting; Volckaert, Thomas; Redente, Elizabeth F.; Hopkins, Seantel; Klinkhammer, Kylie; Wasnick, Roxana; Chao, Cho-Ming; Yuan, Jie; Zhang, Jin-San; Yao, Changfu; Majka, Susan; Stripp, Barry R.; Gunther, Andreas; Riches, David W. H.; Bellusci, Saverio; Thannickal, Victor J.; De Langhe, Stijn P.
Jahr der Veröffentlichung: 2019
Seiten: 1041-1055
Zeitschrift: Stem Cell Reports
Bandnummer: 12
Heftnummer: 5
ISSN: 2213-6711
Open Access Status: Gold
DOI Link: https://doi.org/10.1016/j.stemcr.2019.04.003
Verlag: Cell Press
Abstract:
Idiopathic pulmonary fibrosis is a common form of interstitial lung disease resulting in alveolar remodeling and progressive loss of pulmonary function because of chronic alveolar injury and failure to regenerate the respiratory epithelium. Histologically, fibrotic lesions and honeycomb structures expressing atypical proximal airway epithelial markers replace alveolar structures, the latter normally lined by alveolar type 1 (AT1) and AT2 cells. Bronchial epithelial stem cells (BESCs) can give rise to AT2 and AT1 cells or honeycomb cysts following bleomycin-mediated lung injury. However, little is known about what controls this binary decision or whether this decision can be reversed. Here we report that inactivation of Fgfr2b in BESCs impairs their contribution to both alveolar epithelial regeneration and honeycomb cysts after bleomycin injury. By contrast overexpression of Fgf10 in BESCs enhances fibrosis resolution by favoring the more desirable outcome of alveolar epithelial regeneration over the development of pathologic honeycomb cysts.
Zitierstile
Harvard-Zitierstil: Yuan, T., Volckaert, T., Redente, E., Hopkins, S., Klinkhammer, K., Wasnick, R., et al. (2019) FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury, Stem Cell Reports, 12(5), pp. 1041-1055. https://doi.org/10.1016/j.stemcr.2019.04.003
APA-Zitierstil: Yuan, T., Volckaert, T., Redente, E., Hopkins, S., Klinkhammer, K., Wasnick, R., Chao, C., Yuan, J., Zhang, J., Yao, C., Majka, S., Stripp, B., Gunther, A., Riches, D., Bellusci, S., Thannickal, V., & De Langhe, S. (2019). FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury. Stem Cell Reports. 12(5), 1041-1055. https://doi.org/10.1016/j.stemcr.2019.04.003
Schlagwörter
CONTRIBUTE; MUC5B; PROGENITOR CELLS; PULMONARY-FIBROSIS
