Journalartikel

Jahr der Veröffentlichung: 2019

Seiten: 151-160

Zeitschrift: Translational Pediatrics

Bandnummer: 8

Heftnummer: 2

ISSN: 2224-4336

eISSN: 2224-4344

Open Access Status: Gold

DOI Link: https://doi.org/10.21037/tp.2019.04.09

Verlag: AME Publishing

Abstract: 
Dilated cardiomyopathy (DCM) is a leading cause of cardiac death in children. Current therapeutic strategies are focused on improving symptoms of congestive heart failure (CHF); the potentials of cardiac regeneration especially in infants and young children are neglected in particular when DCM is classified as "end-stage". Heart transplantation (HTx) serves as the only life-saving option, despite is palliative character with limited survival time. Therapeutic alternatives are strongly needed, but already existing though less used; presupposed, that cardiac dysfunction and its treatment are not reduced to the four components of heart rate (rhythm), myocardial contractility, preload and afterload. A paradigm shift in the treatment of pediatric heart failure can be achieved by modifying ventricular afterload with improving contra-lateral ventricular function. Adverse ventricular-ventricular interactions (VVI) have the potential to harness them for therapeutic benefit. Surgical placement of a pulmonary artery banding (PAB) utilized in infants and young children with LV-DCM and preserved RV function are able to improve LV function via VVI; it is hypothesized, that functional recovery can be achieved in almost 80% especially of infants with LV-DCM despite criteria for listing to orthotopic HTx. The review summarizes details of the current perioperative treatment enabling each pediatric heart center to utilize rPAB as a strategy for functional recovery, even in centers without the option for Htx. Of course, future studies are needed to delineate the geometrical, temporal and molecular mechanisms of PA-banding-induced ventricular crosstalk and to examine their potential modulation through mechanical, electrophysiological and pharmacological interventions, but our patients are born, now.

Harvard-Zitierstil: Schranz, D., Recla, S., Malcic, I., Kerst, G., Mini, N. and Akintuerk, H. (2019) Pulmonary artery banding in dilative cardiomyopathy of young children: review and protocol based on the current knowledge, Translational Pediatrics, 8(2), pp. 151-160. https://doi.org/10.21037/tp.2019.04.09

APA-Zitierstil: Schranz, D., Recla, S., Malcic, I., Kerst, G., Mini, N., & Akintuerk, H. (2019). Pulmonary artery banding in dilative cardiomyopathy of young children: review and protocol based on the current knowledge. Translational Pediatrics. 8(2), 151-160. https://doi.org/10.21037/tp.2019.04.09