Journal article

Publication year: 2019

Pages: 540-543

Journal: The Journal of Infectious Diseases

Volume number: 219

Issue number: 4

ISSN: 0022-1899

eISSN: 1537-6613

DOI Link: https://doi.org/10.1093/infdis/jiy554

Publisher: Oxford University Press

Abstract: 
Influenza A virus (IAV) causes severe respiratory infections and alveolar epithelial damage resulting in acute respiratory distress syndrome (ARDS). Extracellular vesicles (EVs) have been shown to mediate cellular crosstalk in inflammation by transfer of microRNAs (miRNAs). In this study, we found significant changes in the miRNA composition of EVs in the bronchoalveolar lavage fluid from patients with IAV-induced ARDS. Among the 9 significantly deregulated microRNAs, miR-17-5p was upregulated in patients' BALF and in EVs of IAV-infected lung epithelial cells (A549). In these cells, transfer of miR-17-5p strongly downregulated expression of the antiviral factor Mx1 and significantly enhanced IAV replication.

Harvard Citation style: Scheller, N., Herold, S., Kellner, R., Bertrams, W., Jung, A., Janga, H., et al. (2019) Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome, The Journal of Infectious Diseases, 219(4), pp. 540-543. https://doi.org/10.1093/infdis/jiy554

APA Citation style: Scheller, N., Herold, S., Kellner, R., Bertrams, W., Jung, A., Janga, H., Greulich, T., Schulte, L., Vogelmeier, C., Lohmeyer, J., & Schmeck, B. (2019). Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome. The Journal of Infectious Diseases. 219(4), 540-543. https://doi.org/10.1093/infdis/jiy554