Journalartikel
Autorenliste: Mayer, Konstantin; Sommer, Natascha; Hache, Karl; Hecker, Andreas; Reiche, Sylvia; Schneck, Emmanuel; Weissmann, Norbert; Seeger, Werner; Hecker, Matthias
Jahr der Veröffentlichung: 2019
Seiten: 53-65
Zeitschrift: Lipids
Bandnummer: 54
Heftnummer: 1
ISSN: 0024-4201
eISSN: 1558-9307
DOI Link: https://doi.org/10.1002/lipd.12119
Verlag: Wiley
Abstract:
Severe inflammatory disorders such as sepsis are a major cause of morbidity and mortality worldwide. Mitochondrial dysfunction is regarded as a key feature involved in inflammation pathogenesis. In the present study, we investigated the impact of the omega-3 fatty acid-derived lipid mediator Resolvin E1 (RvE1) on mitochondrial function in experimental pulmonary inflammation. RvE1 was found to exert anti-inflammatory properties in human alveolar epithelial cells during severe inflammation. RvE1 is capable of restoring inflammation-induced mitochondrial dysfunction and the impaired imbalance of mitochondrial fission and fusion. Experimental inhibition of mitochondrial fission with Mdivi-1 in our model is associated with a significantly reduced inflammatory response and improved mitochondrial function. These findings suggest a novel functional mechanism for the beneficial effects of RvE1 in experimental pulmonary inflammatory reactions.
Zitierstile
Harvard-Zitierstil: Mayer, K., Sommer, N., Hache, K., Hecker, A., Reiche, S., Schneck, E., et al. (2019) Resolvin E1 Improves Mitochondrial Function in Human Alveolar Epithelial Cells during Severe Inflammation, Lipids, 54(1), pp. 53-65. https://doi.org/10.1002/lipd.12119
APA-Zitierstil: Mayer, K., Sommer, N., Hache, K., Hecker, A., Reiche, S., Schneck, E., Weissmann, N., Seeger, W., & Hecker, M. (2019). Resolvin E1 Improves Mitochondrial Function in Human Alveolar Epithelial Cells during Severe Inflammation. Lipids. 54(1), 53-65. https://doi.org/10.1002/lipd.12119
Schlagwörter
FISSION; FUSION; LEUKOTRIENE B-4; LIPID EMULSIONS; Resolvin
