Journal article

Publication year: 2019

Pages: 302-312

Journal: European Journal of Immunology

Volume number: 49

Issue number: 2

ISSN: 0014-2980

eISSN: 1521-4141

Open access status: Bronze

DOI Link: https://doi.org/10.1002/eji.201847883

Publisher: Wiley

Abstract: 
Allergen specific tolerance induction efficiently ameliorates subsequent allergen induced inflammatory responses. The underlying regulatory mechanisms have been attributed mainly to interleukin (IL)-10 produced by diverse hematopoietic cells, while targets of IL-10 in allergen specific tolerance induction have not yet been well defined. Here, we investigate potential cellular targets of IL-10 in allergen specific tolerance induction using mice with a cell type specific inactivation of the IL-10 receptor gene. Allergic airway inflammation was effectively prevented by tolerance induction in mice with IL-10 receptor (IL-10R) deficiency in T or B cells. Similarly, IL-10R on monocytes/macrophages and/or neutrophils was not required for tolerance induction. In contrast, tolerance induction was impaired in mice that lack IL-10R on dendritic cells: those mice developed an allergic response characterized by a pronounced neutrophilic lung infiltration, which was not ameliorated by tolerogenic treatment. In conclusion, our results show that allergen specific tolerance can be effectively induced without a direct impact of IL-10 on cells of the adaptive immune system, and highlight dendritic cells, but not macrophages nor neutrophils, as the main target of IL-10 during tolerance induction.

Harvard Citation style: Dolch, A., Kunz, S., Dorn, B., Alessandrini, F., Mueller, W., Jack, R., et al. (2019) IL-10 signaling in dendritic cells is required for tolerance induction in a murine model of allergic airway inflammation, European Journal of Immunology, 49(2), pp. 302-312. https://doi.org/10.1002/eji.201847883

APA Citation style: Dolch, A., Kunz, S., Dorn, B., Alessandrini, F., Mueller, W., Jack, R., Martin, S., Roers, A., & Jakob, T. (2019). IL-10 signaling in dendritic cells is required for tolerance induction in a murine model of allergic airway inflammation. European Journal of Immunology. 49(2), 302-312. https://doi.org/10.1002/eji.201847883