Journal article

Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study


Authors listWestphal, Sabine; Stoppe, Christian; Gruenewald, Matthias; Bein, Berthold; Renner, Jochen; Cremer, Jochen; Coburn, Mark; Schaelte, Gereon; Boening, Andreas; Niemann, Bernd; Kletzin, Frank; Roesner, Jan; Strouhal, Ulrich; Reyher, Christian; Laufenberg-Feldmann, Rita; Ferner, Marion; Brandes, Ivo F.; Bauer, Martin; Kortgen, Andreas; Stehr, Sebastian N.; Wittmann, Maria; Baumgarten, Georg; Struck, Rafael; Meyer-Treschan, Tanja; Kienbaum, Peter; Heringlake, Matthias; Schoen, Julika; Sander, Michael; Treskatsch, Sascha; Smul, Thorsten; Wolwender, Ewa; Schilling, Thomas; Degenhardt, Frauke; Franke, Andre; Mucha, Soeren; Tittmann, Lukas; Kohlhaas, Madeline; Fuernau, Georg; Brosteanu, Oana; Hasenclever, Dirk; Zacharowski, Kai; Meybohm, Patrick; Stevanovic, Ana; Rossaint, Rolf; Felzen, Marc; Goetzenich, Andreas; Moormann, Tobias; Chalk, Katharina; Knuefermann, Pascal; Boehm, Olaf; Hoeft, Andreas; Winterhalter, Michael; Iken, Sonja; Weber, Christian; Wiedenbeck, Carolin; Schwarzmann, Gerhard; Pense, Karin; Zierer, Andreas; Fichtlscherer, Stephan; Goerlach, Gerold; Wollbrueck, Matthias; Boening, Ursula; Weigand, Markus; Strauchmann, Julia; August, Konrad; Morsbach, Kai U.; Paxian, Markus; Reinhard, Konrad; Gruenewald, Matthias; Scholz, Jens; Broch, Ole; Francksen, Helga; Albrecht, Martin; Kuhr, Bernd; Heinze, Hermann; Paarmann, Hauke; Sievers, Hans-Hinrich; Klotz, Stefan; Hachenberg, Thomas; Werner, Christian; Mauff, Susanne; Alms, Angela; Bergt, Stefan; Roewer, Norbert

Publication year2019

JournalBMC Cardiovascular Disorders

Volume number19

ISSN1471-2261

Open access statusGold

DOI Linkhttps://doi.org/10.1186/s12872-019-1002-x

PublisherBioMed Central


Abstract
BackgroundThe aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.MethodsWe conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.ResultsA total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p=3.77x10(-8)) and 139 (adjusted for all other outcomes) SNPs showed promising association with p<1x10(-5) from the GWAS.ConclusionsWe identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.Trial registrationThe study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.



Citation Styles

Harvard Citation styleWestphal, S., Stoppe, C., Gruenewald, M., Bein, B., Renner, J., Cremer, J., et al. (2019) Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study, BMC Cardiovascular Disorders, 19, Article 26. https://doi.org/10.1186/s12872-019-1002-x

APA Citation styleWestphal, S., Stoppe, C., Gruenewald, M., Bein, B., Renner, J., Cremer, J., Coburn, M., Schaelte, G., Boening, A., Niemann, B., Kletzin, F., Roesner, J., Strouhal, U., Reyher, C., Laufenberg-Feldmann, R., Ferner, M., Brandes, I., Bauer, M., Kortgen, A., ...Roewer, N. (2019). Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study. BMC Cardiovascular Disorders. 19, Article 26. https://doi.org/10.1186/s12872-019-1002-x



Keywords


ACUTE KIDNEY INJURYCardiac surgeryCEREBRAL ISCHEMIA/REPERFUSION INJURYDeliriumINFLAMMATORY RESPONSEMyocardial infarctionPHLPP2

Last updated on 2025-10-06 at 10:57