Journalartikel

Jahr der Veröffentlichung: 2018

Seiten: 205-213

Zeitschrift: Ophthalmic Research: Journal for Translational and Clinical Research

Bandnummer: 60

Heftnummer: 4

ISSN: 0030-3747

eISSN: 1423-0259

DOI Link: https://doi.org/10.1159/000484631

Verlag: Karger Publishers

Abstract: 
Aim: Comparison of choroidal thickness (CT) and foveal morphology as seen with swept-source optical coherence tomography (SS-OCT) in children with a history of treated or spontaneously regressed retinopathy of prematurity (tROP or srROP) to assess the impact on best-corrected visual acuity (BCVA). Methods: CT was measured by SS-OCT (DRI-OCT Triton; Topcon, USA) single scans of a 6-mm diameter around the fovea in 17 children with tROP or srROP (4-7 years of age) and compared to 25 controls (age-matched children and adults). The disproportion of the outer nuclear layer and inner retinal layers at the fovea (i.e., the ONL+/IRL ratio) as a measure of macular developmental arrest (MDA) was manually analyzed. BCVA was tested with ETDRS letter charts and correlated with the morphology. Results: CT was significantly thinner in children with tROP and srROP compared to term-born healthy children (nKids) at all measurement marks (p < 0.001), and mostly affected in the subfoveal area. tROP showed the lowest CT. CT allowed no direct conclusion about ONL+/IRL, but correlated positively with BCVA. Conclusions: Reduced CT in children with a history of ROP is linked to ROP severity. These findings overlap with the degree of MDA. CT appears to be involved in ROP, but MDA showed a higher impact on the BCVA of the examined cohort.

Harvard-Zitierstil: Bowl, W., Bowl, M., Schweinfurth, S., Holve, K., Andrassi-Darida, M., Stieger, K., et al. (2018) Choroidal Thickness with Swept-Source Optical Coherence Tomography versus Foveal Morphology in Young Children with a History of Prematurity, Ophthalmic Research, 60(4), pp. 205-213. https://doi.org/10.1159/000484631

APA-Zitierstil: Bowl, W., Bowl, M., Schweinfurth, S., Holve, K., Andrassi-Darida, M., Stieger, K., & Lorenz, B. (2018). Choroidal Thickness with Swept-Source Optical Coherence Tomography versus Foveal Morphology in Young Children with a History of Prematurity. Ophthalmic Research. 60(4), 205-213. https://doi.org/10.1159/000484631