Journal article

Publication year: 2018

Pages: 475-481

Journal: Acta Neurologica Scandinavica

Volume number: 138

Issue number: 6

ISSN: 0001-6314

eISSN: 1600-0404

DOI Link: https://doi.org/10.1111/ane.13015

Publisher: Wiley

Abstract: 

Objectives Neuropsychological sequelae are a feature of benign epilepsy with centrotemporal spikes (BECTS) in children. A correlation between the frequency of interictal EEG discharges and the cognitive as well as behavioral profile of the patients has been suspected but not proven.

Materials and methods Children with BECTS that had not yet been treated were included into a randomized controlled trial. In the initial visit, EEGs were recorded. The frequency of interictal discharges was quantified. Correlations between the discharge frequency and the performance in a neuropsychological test battery were examined.

Results The cognitive test results were within or slightly above normal range (Culture-free intelligence test: 99.4%-confidence interval [CI]: [50.3, 59.9], test standardized to a population mean of 50). Parent-reported behavioral abnormalities were statistically significantly increased (CBCL total score CI: [51.9, 61.9], population mean as above). Correlations between the frequency of interictal epileptic discharges and the test results could not be identified (lowest encountered P-value: 0.034, not significant after correction for multiple testing).

Conclusion The data do not support the hypothesis that the frequency of the interictal EEG discharges influences the neurocognitive performance or behavioral parameters of children with BECTS.

Harvard Citation style: Tacke, M., Rupp, N., Gerstl, L., Heinen, F., Vill, K., Bonfert, M., et al. (2018) Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology, Acta Neurologica Scandinavica, 138(6), pp. 475-481. https://doi.org/10.1111/ane.13015

APA Citation style: Tacke, M., Rupp, N., Gerstl, L., Heinen, F., Vill, K., Bonfert, M., Neubauer, B., Bast, T., & Borggraefe, I. (2018). Benign epilepsy with centrotemporal spikes: Correlating spike frequency and neuropsychology. Acta Neurologica Scandinavica. 138(6), 475-481. https://doi.org/10.1111/ane.13015