Journal article
Authors list: Gierth, Michael; Zeman, Florian; Denzinger, Stefan; Vetterlein, Malte W.; Fisch, Margit; Bastian, Patrick J.; Syring, Isabella; Ellinger, Joerg; Mueller, Stephan C.; Herrmann, Edwin; Gilfrich, Christian; May, Matthias; Pycha, Armin; Wagenlehner, Florian M.; Vallo, Stefan; Bartsch, Georg; Haferkamp, Axel; Grimm, Marc-Oliver; Roigas, Jan; Protzel, Chris; Hakenberg, Oliver W.; Fritsche, Hans-Martin; Burger, Maximilian; Aziz, Atiqullah; Mayr, Roman
Publication year: 2018
Pages: 16-24
Journal: Urologia Internationalis
Volume number: 101
Issue number: 1
ISSN: 0042-1138
eISSN: 1423-0399
DOI Link: https://doi.org/10.1159/000488466
Publisher: Karger Publishers
Abstract:
Background/Aims/Objectives: To evaluate the influence of body mass index (BMI) on complications and oncological outcomes in patients undergoing radical cystectomy (RC). Methods: Clinical and histopathological parameters of pa-tients have been prospectively collected within the "PRO-spective MulticEnTer RadIcal Cystectomy Series 2011". BMI was categorized as normal weight (< 25 kg/m(2)), overweight (>= 25-29.9 kg/m(2)) and obesity (>= 30 kg/m(2)). The association between BMI and clinical and histopathological endpoints was examined. Ordinal logistic regression models were applied to assess the influence of BMI on complication rate and survival. Results: Data of 671 patients were eligible for final analysis. Of these patients, 26% (n = 175) showed obesity. No significant association of obesity on tumour stage, grade, lymph node metastasis, blood loss, type of urinary diversion and 90-day mortality rate was found. According to the American Society of Anesthesiologists score, local lymph node (NT) stage and operative case load patients with higher BMI had significantly higher probabilities of severe complications 30 days after RC (p = 0.037). The overall survival rate of obese patients was superior to normal weight patients (p = 0.019). Conclusions: There is no evidence of correlation between obesity and worse oncological outcomes after RC. While obesity should not be a parameter to exclude patients from cystectomy, surgical settings need to be aware of higher short-term complication risks and obese patients should be counselled - accordingly. (C) 2018 S. Karger AG, Basel
Citation Styles
Harvard Citation style: Gierth, M., Zeman, F., Denzinger, S., Vetterlein, M., Fisch, M., Bastian, P., et al. (2018) Influence of Body Mass Index on Clinical Outcome Parameters, Complication Rate and Survival after Radical Cystectomy: Evidence from a Prospective European Multicentre Study, Urologia Internationalis, 101(1), pp. 16-24. https://doi.org/10.1159/000488466
APA Citation style: Gierth, M., Zeman, F., Denzinger, S., Vetterlein, M., Fisch, M., Bastian, P., Syring, I., Ellinger, J., Mueller, S., Herrmann, E., Gilfrich, C., May, M., Pycha, A., Wagenlehner, F., Vallo, S., Bartsch, G., Haferkamp, A., Grimm, M., Roigas, J., ...Mayr, R. (2018). Influence of Body Mass Index on Clinical Outcome Parameters, Complication Rate and Survival after Radical Cystectomy: Evidence from a Prospective European Multicentre Study. Urologia Internationalis. 101(1), 16-24. https://doi.org/10.1159/000488466
Keywords
Bladder cancer; BLADDER-CANCER; BLOOD-LOSS; CARCINOMA; COHORT; Radical cystectomy; Urothelial carcinoma; WORSE ONCOLOGICAL OUTCOMES
