Journal article
Authors list: Meyer, Alain; Scire, Carlo Alberto; Talarico, Rosaria; Alexander, Tobias; Amoura, Zahir; Avcin, Tadej; Barsotti, Simone; Beretta, Lorenzo; Blagojevic, Jelena; Burmester, Gerd; Cavazzana, Ilaria; Cherrin, Patrick; Damian, Laura; Doria, Andrea; Fonseca, Joao Eurico; Furini, Federica; Galetti, Ilaria; Houssiau, Frederic; Krieg, Thomas; Larosa, Maddalena; Launay, David; Campanilho-Marques, Raquel; Martin, Thierry; Matucci-Cerinic, Marco; Moinzadeh, Pia; Montecucco, Carlomaurizio; Moraes-Fontes, Maria Francisca; Mouthon, Luc; Neri, Rossella; Paolino, Sabrina; Piette, Yves; Rednic, Simona; Tamirou, Farah; Tincani, Angela; Toplak, Natasa; Bombardieri, Stefano; Hachulla, Eric; Mueller-Ladner, Ulf; Schneider, Matthias; Smith, Vanessa; Vieira, Ana; Cutolo, Maurizio; Mosca, Marta; Cavagna, Lorenzo
Publication year: 2018
Journal: RMD Open: Rheumatic and Musculoskeletal Diseases
Volume number: 4
ISSN: 2056-5933
DOI Link: https://doi.org/10.1136/rmdopen-2018-000784
Publisher: BMJ Publishing Group
Abstract:
Idiopathic inflammatory myopathies (IIMs) encompass a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and inflammation, but in antisynthetase syndrome arthritis and interstitial lung disease are more frequent and often inaugurate the disease. Clinical practice guidelines (CPGs) have been proposed for IIMs, but they are sparse and heterogeneous. This work aimed at identifying: i) current available CPGs for IIMs, ii) patients' and clinicians' unmet needs not covered by CPGs. It has been performed in the framework of the European Reference Network on rare and complex connective tissue and musculoskeletal diseases (ReCONNET), a network of centre of expertise and patients funded by the European Union's Health Programme. Fourteen original CPGs were identified, notably recommending that: i) extra-muscular involvements should be assessed; ii) corticosteroids and methotrexate or azathioprine are first-line therapies of IIMs. iii) IVIG is a treatment of resistant-DM that may be also used in other resistant-IIMs; iv) physical therapy and sun protection (in DM patients) are part of the treatment; v) tumour screening for patients with DM include imaging of chest, abdomen, pelvis and breast (in woman) along with colonoscopy (in patients over 50 years); vi) disease activity and damages should be monitor using standardised and validated tools. Yet, only half of these CPGs were evidence-based. Crucial unmet needs were identified both by patients and clinicians. In particular, there was a lack of large multidisciplinary working group and of patients' preferences. The following fields were not or inappropriately targeted: diagnosis; management of extra-muscular involvements other than skin; co-morbidities and severe manifestations.
Citation Styles
Harvard Citation style: Meyer, A., Scire, C., Talarico, R., Alexander, T., Amoura, Z., Avcin, T., et al. (2018) Idiopathic inflammatory myopathies: state of the art on clinical practice guidelines, RMD OPEN, 4, Article UNSP e000784. https://doi.org/10.1136/rmdopen-2018-000784
APA Citation style: Meyer, A., Scire, C., Talarico, R., Alexander, T., Amoura, Z., Avcin, T., Barsotti, S., Beretta, L., Blagojevic, J., Burmester, G., Cavazzana, I., Cherrin, P., Damian, L., Doria, A., Fonseca, J., Furini, F., Galetti, I., Houssiau, F., Krieg, T., ...Cavagna, L. (2018). Idiopathic inflammatory myopathies: state of the art on clinical practice guidelines. RMD OPEN. 4, Article UNSP e000784. https://doi.org/10.1136/rmdopen-2018-000784
Keywords
CONSENSUS; HIKERS FEET; INTRAVENOUS IMMUNOGLOBULIN; JUVENILE DERMATOMYOSITIS; MYOSITIS; POLYMYOSITIS
