Journal article
Authors list: Jelenik, Tomas; Dille, Matthias; Muller-Luhlhoff, Sabrina; Kabra, Dhiraj G.; Zhou, Zhou; Binsch, Christian; Hartwig, Sonja; Lehr, Stefan; Chadt, Alexandra; Peters, Eva M. J.; Kruse, Johannes; Roden, Michael; Al-Hasani, Hadi; Castaneda, Tamara R.
Publication year: 2018
Pages: 126-138
Journal: Molecular Metabolism
Volume number: 16
ISSN: 2212-8778
Open access status: Gold
DOI Link: https://doi.org/10.1016/j.molmet.2018.06.012
Publisher: Elsevier
Objective: Post-traumatic stress disorder (PTSD) increases type 2 diabetes risk, yet the underlying mechanisms are unclear. We investigated how early-life exposure to chronic stress affects long-term insulin sensitivity. Methods: C57Bl/6J mice were exposed to chronic variable stress for 15 days (Cvs) and then recovered for three months without stress (Cvs3m). Results: Cvs mice showed markedly increased plasma corticosterone and hepatic insulin resistance. Cvs3m mice exhibited improved whole-body insulin sensitivity along with enhanced adipose glucose uptake and skeletal muscle mitochondrial function and fatty acid oxidation. Plasma FGF21 levels were substantially increased and associated with expression of genes involved in fatty acid oxidation and formation of brown-like adipocytes. In humans, serum FGF21 levels were associated with stress coping long time after the exposure. Conclusions: Early-life exposure to chronic stress leads to long term improvements in insulin sensitivity, oxidative metabolism and adipose tissue remodeling. FGF21 contributes to a physiological memory mechanism to maintain metabolic homeostasis. (C) 2018 The Authors. Published by Elsevier GmbH.
Abstract:
Citation Styles
Harvard Citation style: Jelenik, T., Dille, M., Muller-Luhlhoff, S., Kabra, D., Zhou, Z., Binsch, C., et al. (2018) FGF21 regulates insulin sensitivity following long-term chronic stress, Molecular Metabolism, 16, pp. 126-138. https://doi.org/10.1016/j.molmet.2018.06.012
APA Citation style: Jelenik, T., Dille, M., Muller-Luhlhoff, S., Kabra, D., Zhou, Z., Binsch, C., Hartwig, S., Lehr, S., Chadt, A., Peters, E., Kruse, J., Roden, M., Al-Hasani, H., & Castaneda, T. (2018). FGF21 regulates insulin sensitivity following long-term chronic stress. Molecular Metabolism. 16, 126-138. https://doi.org/10.1016/j.molmet.2018.06.012
Keywords
Chronic variable stress; PSYCHOLOGICAL STRESS; PTSD; White adipose tissue
