Journal article

Publication year: 2018

Pages: 463-473

Journal: Matrix Biology

Volume number: 68-69

ISSN: 0945-053X

eISSN: 1569-1802

Open access status: Hybrid

DOI Link: https://doi.org/10.1016/j.matbio.2017.12.012

Publisher: Elsevier

Abstract: 
Liver fibrosis, a reversible wound-healing response to chronic cellular injury, reflects a balance between liver repair and progressive substitution of the liver parenchyma by scar tissue. Complex mechanisms that underlie liver fibrogenesis are summarized to provide the basis for generating targeted therapies to reverse fibrogenesis and improve the outcomes of patients with chronic liver disease. This minireview presents some pathophysiological aspects of liver fibrosis as a dynamic process and elucidates matrix metalloproteinases (MMPs) and their role within as well as beyond matrix degradation. Open questions remain, whether inhibition of fibrogenesis or induction of fibrolysis is the key mechanism to resolve fibrosis. And a point of principle might be whether regeneration of liver cirrhosis is possible. Will we ever cure fibrosis? (C) 2018 The Author. Published by Elsevier B.V.

Harvard Citation style: Roeb, E. (2018) Matrix metalloproteinases and liver fibrosis (translational aspects), Matrix Biology, 68-69, pp. 463-473. https://doi.org/10.1016/j.matbio.2017.12.012

APA Citation style: Roeb, E. (2018). Matrix metalloproteinases and liver fibrosis (translational aspects). Matrix Biology. 68-69, 463-473. https://doi.org/10.1016/j.matbio.2017.12.012