Background: The extent of aortic valve calcification is an important determinant of procedural success in transcatheter aortic valve implantation (TAVI). We sought to validate device landing zone calcium volume (DLZ-CV) measurements on contrast-enhanced multidetector computed tomography (MDCT) with non-contrast-enhanced scans as reference.

Methods: We determined DLZ-CV in 141 patients undergoing transfemoral TAVI. Non-contrast-enhanced images were analyzed using a threshold of 130 HU as reference (DLZ-CV130). For contrast-enhanced scans, we applied various thresholds including 450 HU (DLZ-CV450), 850 HU (DLZ-CV850), mean aortic attenuation (Atten(AO)) + 2 SD (DLZ-CV2SD),Atten(AO) + 4 SD (DLZ-CV4SD), Atten(AO) + 4 SD + 5 mm(3) volume filter (DLZ-CV4SD+), and based on visual estimation (DLZ-CVvis). We compared DLZ-CV values between patients with versus without paravalvular leak (PVL), and between patients with versus without post-dilatation stratified by the type of prosthesis.

Results: All DLZ-CV measurements on contrast-enhanced scans significantly differed from DLZ-CV130 (p < 0.001 for all comparisons). The best approximation to DLZ-CV130 was achieved with DLZ-CV4SD (508 mm(3) [332-772]; Pearson correlation: R = 0.87, p < 0.001; Bland-Altman: mean difference 1339 mm(3) [limits of agreement. 79;2600]). Moreover, DLZ-CV4SD+ allowed for discrimination of PVL >= 1 degrees or the need for post-dilatation in patients receiving self-expanding prostheses. Procedural outcome using balloon-expandable prostheses was independent of DLZ-CV.

Conclusion: Measurement of DLZ-CV using contrast-enhanced scans with unadjusted thresholds results in incorrect estimation of the calcium volume. The use of a scan-specific individual HU threshold including a volume filter (DLZ-CV4SD+) provides the best approximation to the reference and allows for discrimination of PVL >= 1 degrees in patients receiving the Acurate neo prosthesis. (C) 2018 Elsevier B.V. All rights reserved.