Journal article
Authors list: Flommersfeld, Sabine; Mand, Carsten; Kuehne, Christian A.; Bein, Gregor; Ruchholtz, Steffen; Sachs, Ulrich J.
Publication year: 2018
Pages: 158-161
Journal: Transfusion Medicine and Hemotherapy
Volume number: 45
Issue number: 3
ISSN: 1660-3796
eISSN: 1660-3818
Open access status: Green
DOI Link: https://doi.org/10.1159/000485388
Publisher: Karger Publishers
Abstract:
Background: Immediate supply of red blood cell (RBC) concentrates is crucial in the initial treatment of exsanguinating patients in the emergency room. General shortage of RhD-RBCs has led to protocols in which patients with unknown blood groups are initially transfused with group O, RhD+ RBCs. Limited data are available regarding the safety of such an approach. Methods: Transfusion protocols for all multiple injured patients from the regional polytrauma database were retrospectively analyzed over a period of 5 years. Data on side effects were retrieved from the local safety update registry. Follow-up data were obtained from patients with identified RhD-incompatible transfusions. Results: In total, 823 patients were registered as multiple injured in the database. An immediate transfusion of 259 units (mean number of units 4, range 1-6) group O, RhD+ RBCs was initiated in 62 of them. 14 of these patients were RhD- and received 60 units of RhD-incompatible RBCs in the emergency room. In the later course RhD-patients received additional 185 incompatible transfusions (13; 1-31). The overall seroconversion rate was 50%. No adverse outcome due to incompatible transfusion was observed. Conclusions: Initial supply with group O, RhD+ RBCs in multiple injured patients appears to be safe. Significant numbers of RhD-units can be saved for use in other patients. (c) 2018 S. Karger GmbH, Freiburg
Citation Styles
Harvard Citation style: Flommersfeld, S., Mand, C., Kuehne, C., Bein, G., Ruchholtz, S. and Sachs, U. (2018) Unmatched Type O RhD plus Red Blood Cells in Multiple Injured Patients, Transfusion Medicine and Hemotherapy, 45(3), pp. 158-161. https://doi.org/10.1159/000485388
APA Citation style: Flommersfeld, S., Mand, C., Kuehne, C., Bein, G., Ruchholtz, S., & Sachs, U. (2018). Unmatched Type O RhD plus Red Blood Cells in Multiple Injured Patients. Transfusion Medicine and Hemotherapy. 45(3), 158-161. https://doi.org/10.1159/000485388
Keywords
ALLOIMMUNIZATION; ANTI-D; Emergency transfusion; IMMUNIZATION; Non-cross-matched transfusions; RESUSCITATION; TRANSFUSION; TRAUMA PATIENTS; Type O RhD plus supply; UNCROSSMATCHED BLOOD; VOLUNTEERS
