Journal article
Authors list: Stahl, Mirjam; Graeber, Simon Y.; Joachim, Cornelia; Barth, Sandra; Ricklefs, Isabell; Diekmann, Gesa; Kopp, Matthias V.; Naehrlich, Lutz; Mall, Marcus A.
Publication year: 2018
Pages: 249-255
Journal: Journal of Cystic Fibrosis
Volume number: 17
Issue number: 2
ISSN: 1569-1993
eISSN: 1873-5010
Open access status: Bronze
DOI Link: https://doi.org/10.1016/j.jcf.2017.08.001
Publisher: Elsevier
Background: Lung clearance index (LCI) detects early ventilation inhomogeneity and has been suggested as sensitive endpoint in multicenter intervention trials in infants and preschoolers with cystic fibrosis (CF). However, the feasibility of multicenter LCI in this age group has not been determined. We, therefore, investigated the feasibility of LCI in infants and preschoolers with and without CF in a three-center setting. Methods: Following central training, standardized SF6-MBW measurements were performed in 73 sedated children (10 controls, 49 with CF and 14 with other lung diseases), mean age 2.3 +/- 1.2 years across three centers, and data were analyzed centrally. Results: Overall success rate of LCI measurements was 91.8% ranging from 78.9% to 100% across study sites. LCI was increased in patients with CF (P < 0.05) and with other lung diseases (P < 0.05) compared to controls. Conclusion: Our results support feasibility of LCI as multicenter endpoint in clinical trials in infants and preschoolers with CF. (C) 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Abstract:
Citation Styles
Harvard Citation style: Stahl, M., Graeber, S., Joachim, C., Barth, S., Ricklefs, I., Diekmann, G., et al. (2018) Three-center feasibility of lung clearance index in infants and preschool children with cystic fibrosis and other lung diseases, Journal of Cystic Fibrosis, 17(2), pp. 249-255. https://doi.org/10.1016/j.jcf.2017.08.001
APA Citation style: Stahl, M., Graeber, S., Joachim, C., Barth, S., Ricklefs, I., Diekmann, G., Kopp, M., Naehrlich, L., & Mall, M. (2018). Three-center feasibility of lung clearance index in infants and preschool children with cystic fibrosis and other lung diseases. Journal of Cystic Fibrosis. 17(2), 249-255. https://doi.org/10.1016/j.jcf.2017.08.001
Keywords
CF; Clinical trial endpoint; CLINICAL-TRIALS; COMPUTED-TOMOGRAPHY; Early CF lung disease; HEALTHY INFANTS; HYPERTONIC SALINE; Infant lung function test; LUNG CLEARANCE INDEX; MULTIPLE; Multiple breath washout; VENTILATION INHOMOGENEITY; YOUNG-CHILDREN
