Journalartikel
Autorenliste: Papakonstantinou, Eleni; Mueller, Sabine; Roehrbein, Jan H.; Wieczorek, Dorothea; Kapp, Alexander; Jakob, Thilo; Wedi, Bettina
Jahr der Veröffentlichung: 2018
Seiten: 274-280
Zeitschrift: Contact Dermatitis
Bandnummer: 78
Heftnummer: 4
ISSN: 0105-1873
eISSN: 1600-0536
DOI Link: https://doi.org/10.1111/cod.12956
Verlag: Wiley
Background. The diagnostic approach to drug hypersensitivity includes a detailed medical history, clinical examination, and skin testing and/or oral challenge with a culprit or alternative drug, depending on the type of reaction and the suspected drugs. Although skin testing is considered to be rather safe, cutaneous and systemic, including fatal, reactions have been described. Objectives. To report 3 cases with generalized delayed reactions after skin testing with clindamycin, and to review the existing literature. Methods. Thorough clinical examination, blood tests and prick, intradermal and patch tests were performed in 3 patients. Results. All patients experienced generalized maculopapular exanthema after intradermal and patch testing with clindamycin and amoxicillin in the first patient, and clindamycin alone in the second and third patient. None of the patients showed immediate reactions to skin tests, while positive intradermal reactions after 24 h to amoxicillin and clindamycin were observed in the first patient, and positive intradermal reactions after 24 h to clindamycin were observed in the second and third patients. Conclusions. Skin testing with clindamycin in the diagnosis of drug hypersensitivity carries some risk of adverse reactions. A stepwise and individual diagnostic work-up, considering potential risk factors, and testing in a specialized centre with emergency equipment available is highly recommended.
Abstract:
Zitierstile
Harvard-Zitierstil: Papakonstantinou, E., Mueller, S., Roehrbein, J., Wieczorek, D., Kapp, A., Jakob, T., et al. (2018) Generalized reactions during skin testing with clindamycin in drug hypersensitivity: a report of 3 cases and review of the literature, Contact Dermatitis, 78(4), pp. 274-280. https://doi.org/10.1111/cod.12956
APA-Zitierstil: Papakonstantinou, E., Mueller, S., Roehrbein, J., Wieczorek, D., Kapp, A., Jakob, T., & Wedi, B. (2018). Generalized reactions during skin testing with clindamycin in drug hypersensitivity: a report of 3 cases and review of the literature. Contact Dermatitis. 78(4), 274-280. https://doi.org/10.1111/cod.12956
Schlagwörter
BETA-LACTAM ANTIBIOTICS; drug hypersensitivity; generalized reactions; IMMEDIATE ALLERGIC REACTIONS; NONIMMEDIATE REACTIONS; PENICILLINS; PROVOCATION TESTS; skin testing
