Journalartikel

Jahr der Veröffentlichung: 2018

Seiten: 477-485

Zeitschrift: Haematologica

Bandnummer: 103

Heftnummer: 3

ISSN: 0390-6078

Open Access Status: Gold

DOI Link: https://doi.org/10.3324/haematol.2017.177972

Verlag: Ferrata Storti Foundation

Abstract: 
Patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, non-specific immune stimulation by the tumor or differences in the strength of the patients' anti-lymphoma immunity. We systematically correlated pretreatment concentrations of 25 cytokines with clinical and biological characteristics in a well-characterized cohort of 119 uniformly treated pediatric patients with anaplastic large cell lymphoma. Fifteen patients with anaplastic large cell lymphoma in remission and 11 patients with low-stage B-cell lymphoma served as controls. Concentrations of interleukin-9, interleukin-10, interleukin-17a, hepatocyte growth factor, soluble interleukin-2 receptor, and soluble CD30 were significantly higher in initial sera of patients than in the sera of subjects from both control groups, indicating an anaplastic large cell lymphoma-type cytokine signature. The levels of interleukin-6, interferon-gamma, interferon gamma-induced protein, and soluble interleukin-2 receptor correlated with the stage, initial general condition, minimal disseminated disease, anaplastic lymphoma kinase-antibody titers, and the risk of relapse among patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Only interleukin-6 showed an independent prognostic value in multivariate analyses. Pre-treatment cytokine profiles in patients with anaplastic large cell lymphoma reflect a tumor signature as well as tumor burden and also differences in the strength of the patients' immune response.

Harvard-Zitierstil: Knoerr, F., Damm-Welk, C., Ruf, S., Singh, V., Zimmermann, M., Reiter, A., et al. (2018) Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma, Haematologica, 103(3), pp. 477-485. https://doi.org/10.3324/haematol.2017.177972

APA-Zitierstil: Knoerr, F., Damm-Welk, C., Ruf, S., Singh, V., Zimmermann, M., Reiter, A., & Woessmann, W. (2018). Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Haematologica. 103(3), 477-485. https://doi.org/10.3324/haematol.2017.177972