Journal article

Publication year: 2018

Pages: 73-78

Journal: Journal of Pediatric Gastroenterology and Nutrition

Volume number: 66

Issue number: 1

ISSN: 0277-2116

eISSN: 1536-4801

Open access status: Green

DOI Link: https://doi.org/10.1097/MPG.0000000000001649

Publisher: Wiley

Abstract: 
Objectives:Perianal disease (PD) with fistula and/or abscess formation is a severe complication in Crohn disease (CD). We examined prevalence, incidence, and risk factors for PD development in a pediatric CD cohort.Methods:Patients with CD from the prospective, multicenter registry for inflammatory bowel disease from Germany and Austria (CEDATA-GPGE) were included if diagnosed at the age of 18 years or younger, registered within 3 months after diagnosis, and having at least 2 follow-up visits within the first year of registration. We examined potential risk factors for PD with Kaplan-Meier analysis and a final Cox model considering sex, family history of inflammatory bowel disease, extraintestinal manifestations, disease location, and induction therapy (corticosteroids or nutritional therapy).Results:Of 2406 patients with CD, 742 fulfilled inclusion criteria (59% boys, mean age at diagnosis 12.43.4 years). PD was present at diagnosis in 41 patients (5.5%; 80.9% boys), whereas 32 patients (4.3%, 81.3% male) developed PD during follow-up (mean 2.0 +/- 1.6 years). The cumulative incidence of PD at 12 and 36 months after diagnosis was 3.5% and 7.5%, respectively. Potential risk factors for PD development during follow-up were male sex (hazard ratio=3.2, [95%; confidence interval 1.2-7.8]) and induction therapy with corticosteroids (hazard ratio=2.5 [1.1-5.5]). Diagnostic evaluation at PD diagnosis was incomplete in 40% of affected subjects. PD resolved within 1 year in 50% of cases.Conclusions:Approximately 10% of CD patients in our cohort suffered from PD within the first 3 years of their disease. Male sex and initial corticosteroid therapy were associated with an increased risk to develop PD after diagnosis.

Harvard Citation style: Brueckner, A., Werkstetter, K., de Laffolie, J., Wendt, C., Prell, C., Weidenhausen, T., et al. (2018) Incidence and Risk Factors for Perianal Disease in Pediatric Crohn Disease Patients Followed in CEDATA-GPGE Registry, Journal of Pediatric Gastroenterology and Nutrition, 66(1), pp. 73-78. https://doi.org/10.1097/MPG.0000000000001649

APA Citation style: Brueckner, A., Werkstetter, K., de Laffolie, J., Wendt, C., Prell, C., Weidenhausen, T., Zimmer, K., & Koletzko, S. (2018). Incidence and Risk Factors for Perianal Disease in Pediatric Crohn Disease Patients Followed in CEDATA-GPGE Registry. Journal of Pediatric Gastroenterology and Nutrition. 66(1), 73-78. https://doi.org/10.1097/MPG.0000000000001649