Journal article
Authors list: Cai, Tommaso; Cocci, Andrea; Verze, Paolo; Rizzo, Michele; Palmieri, Alessandro; Liguori, Giovanni; Trombetta, Carlo; Adembri, Chiara; Carini, Marco; Bartoletti, Riccardo; Wagenlehner, Florian M.; Bonkat, Gernot; Mirone, Vincenzo; Johansen, Truls E. Bjerklund; Novelli, Andrea
Publication year: 2018
Pages: 290-295
Journal: Journal of Chemotherapy
Volume number: 30
Issue number: 5
ISSN: 1120-009X
eISSN: 1973-9478
DOI Link: https://doi.org/10.1080/1120009X.2018.1500110
Publisher: Taylor and Francis Group
Abstract:
We present the results of a multicenter retrospective study of 35 difficult-to-treat patients with urinary tract infections associated with indwelling urinary catheters (CAUTIs). All patients received oral administration of 3g fosfomycin trometamol once a day for two days and then with a dose of 3g every 48 h for two weeks. The most commonly isolated strains were: Escherichia coli (65.7%) and Enterococcus spp. (25.7%); prevalence of Extended-Spectrum Beta-Lactamase strains was 48.5%. Six patients (17.1%) had a clinical response after a single dose of fosfomycin trometamol, 12 (34.2%) after two doses and 13 (37.1%) patients had a clinical response after three or more doses. Four patients (11.6%) failed prolonged antibiotic treatment with fosfomycin trometamol. During the follow-up period, 30 out of 35 (85.7%) patients were without symptomatic infections. No significant side effects were reported. In conclusion, fosfomycin trometamol seems to be a valid treatment option in patients with CAUTIs.
Citation Styles
Harvard Citation style: Cai, T., Cocci, A., Verze, P., Rizzo, M., Palmieri, A., Liguori, G., et al. (2018) The use of oral fosfomycin-trometamol in patients with catheter-associated urinary tract infections (CAUTI): new indications for an old antibiotic?, Journal of Chemotherapy, 30(5), pp. 290-295. https://doi.org/10.1080/1120009X.2018.1500110
APA Citation style: Cai, T., Cocci, A., Verze, P., Rizzo, M., Palmieri, A., Liguori, G., Trombetta, C., Adembri, C., Carini, M., Bartoletti, R., Wagenlehner, F., Bonkat, G., Mirone, V., Johansen, T., & Novelli, A. (2018). The use of oral fosfomycin-trometamol in patients with catheter-associated urinary tract infections (CAUTI): new indications for an old antibiotic?. Journal of Chemotherapy. 30(5), 290-295. https://doi.org/10.1080/1120009X.2018.1500110
Keywords
antibiotic stewardship; CAUTI; CLINICAL-PRACTICE GUIDELINES; complicated urinary tract infection; DISEASES SOCIETY; Fosfomycin trometamol; prostatitis; UPDATE
