Journalartikel

Jahr der Veröffentlichung: 2017

Zeitschrift: Gastroenterology Research and Practice

Bandnummer: 2017

ISSN: 1687-6121

eISSN: 1687-630X

Open Access Status: Gold

DOI Link: https://doi.org/10.1155/2017/8424628

Verlag: Wiley

Abstract: 
Aim. To determine the prevalence of anemia and its association with disease severity in children and adolescents with IBD. Methods. CEDATA-GPGE is a registry for pediatric patients with IBD in Germany and Austria from 90 specialized centers. As markers of disease severity, analysis included patient self-assessment on a Likert scale (1-5; 1 = very good) and physicians' general assessment (0 = no activity to 4 = severe disease) and the disease indices. Anemia was defined as hemoglobin concentration below the 3rd percentile. Results. Prevalence of anemia was 65.2% in CD and 60.2% in UC. Anemic CD and UC patients showed significantly worse self-assessment than patients without anemia (average +/- standard deviation; CD: 3.0 +/- 0.9 versus 2.5 +/- 0.9, p < 0 0001; UC: 2.9 +/- 0.9 versus 2.3 +/- 0.9, p < 0 0001). Accordingly, physicians' general assessment (PGA) was significantly worse in anemic than in nonanemic patients in CD (p < 0 0001) and UC (p < 0 0001). PCDAI in anemic CD, p < 0 0001, and PUCAI in anemic UC patients, p < 0 0001, were significantly higher than in nonanemic patients. 40.0% of anemic CD and 47.8% of anemic UC patients received iron during follow-up. Conclusion. Almost 2/3 of pediatric IBD patients are anemic. Patients' self-assessment and disease severity as determined by PGA and activity indices are worse in anemic patients. Contrastingly, only a minority received iron therapy.

Harvard-Zitierstil: de laffolie, J., Laass, M., Scholz, D., Zimmer, K. and Buderus, S. (2017) Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE®, Gastroenterology Research and Practice, 2017, Article 8424628. https://doi.org/10.1155/2017/8424628

APA-Zitierstil: de laffolie, J., Laass, M., Scholz, D., Zimmer, K., & Buderus, S. (2017). Prevalence of Anemia in Pediatric IBD Patients and Impact on Disease Severity: Results of the Pediatric IBD-Registry CEDATA-GPGE®. Gastroenterology Research and Practice. 2017, Article 8424628. https://doi.org/10.1155/2017/8424628