Journal article

Publication year: 2017

Pages: 995-1004

Journal: Clinical Research in Cardiology

Volume number: 106

Issue number: 12

ISSN: 1861-0684

eISSN: 1861-0692

DOI Link: https://doi.org/10.1007/s00392-017-1149-3

Publisher: Springer

Abstract: 

Device landing zone (DLZ) calcification is an important determinant of procedural success in transcatheter aortic valve implantation (TAVI).

To evaluate the impact of DLZ calcification on procedural outcome with different types of transcatheter heart valves (THVs).

Aortic valve calcium density (AVC(dens)) was determined by non-contrast-enhanced computed tomography in 1232 patients undergoing transfemoral TAVI. We stratified the outcome data according to the extent of AVC(dens) (mild, moderate, severe) and compared balloon-expandable (BE) with self-expanding (SE) THV. Moreover, THVs were subdivided according to their radial force (BE: high; SEmod: moderate; SElow: low).

With BE THV, PVR ae2A degrees (2.1 vs. 7.9%; p < 0.001), post-dilatation (12.3 vs. 36.6%; p < 0.001), malpositioning (8.4 vs. 13.0%; p = 0.01), device embolization (0.4 vs. 2.6%; p = 0.004), and the need for a second valve (1.2 vs. 3.6%; p = 0.01) were less frequent than with SE devices, but mean transaortic gradients at discharge were higher [12.0 mmHg (8.0-15.0) vs. 9.0 mmHg (6.0-11.0); p < 0.001], and aortic root injury was more frequent (2.7 vs. 0.8%; p = 0.01). In cases of severe calcification, differences between BE and SE THV regarding PVR, post-dilatation, and hemodynamics were mostly pronounced, followed by patients with moderate AVC(dens). In cases with low AVC(dens), the best outcomes with respect to PVR, pacemaker implantation, and hemodynamics were achieved with SElow THV.

In severe and moderate DLZ calcification, BE devices may have advantages, whereas in mild DLZ calcification, SElow THV showed the most favorable profile.

Harvard Citation style: Kim, W., Blumenstein, J., Liebetrau, C., Rolf, A., Gaede, L., Van Linden, A., et al. (2017) Comparison of outcomes using balloon-expandable versus self-expanding transcatheter prostheses according to the extent of aortic valve calcification, Clinical Research in Cardiology, 106(12), pp. 995-1004. https://doi.org/10.1007/s00392-017-1149-3

APA Citation style: Kim, W., Blumenstein, J., Liebetrau, C., Rolf, A., Gaede, L., Van Linden, A., Arsalan, M., Doss, M., Tijssen, J., Hamm, C., Walther, T., & Moellmann, H. (2017). Comparison of outcomes using balloon-expandable versus self-expanding transcatheter prostheses according to the extent of aortic valve calcification. Clinical Research in Cardiology. 106(12), 995-1004. https://doi.org/10.1007/s00392-017-1149-3