Journal article

Publication year: 2017

Pages: 568-572

Journal: Journal of Zoo and Wildlife Medicine

Volume number: 48

Issue number: 2

ISSN: 1042-7260

eISSN: 1937-2825

DOI Link: https://doi.org/10.1638/20160221R.1

Publisher: American Association of Zoo Veterinarians

Abstract: 
A 14-yr-old, male harbor seal (Phoca vitulina) presented with depression, anorexia, and weight loss. Clinical examination revealed no specific abnormalities. Diagnostic imaging displayed an enlarged mass in the dorso-cranial abdomen. The animal was euthanized due to progressive worsening of symptoms. Grossly, severe emaciation and a massive enlargement of one mesenteric lymph node were found. Microscopically, a neoplastic round cell population with morphologic characteristics of mature lymphocytes infiltrated the mesenteric lymph node as well as the jejunal mucosa and exhibited a marked invasion of the mucosal epithelial layer. Immunohistochemically, the majority of cells expressed CD3, but not CD79(alpha), indicating a T-cell origin of the tumor cells. Microscopic as well as immunohistochemical findings enabled the diagnosis of an epitheliotropic intestinal T-cell lymphoma, a neoplasm that has yet not been described in a harbor seal.

Harvard Citation style: Malberg, S., Gregersen, H., Henrich, M. and Herden, C. (2017) EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA), Journal of Zoo and Wildlife Medicine, 48(2), pp. 568-572. https://doi.org/10.1638/20160221R.1

APA Citation style: Malberg, S., Gregersen, H., Henrich, M., & Herden, C. (2017). EPITHELIOTROPIC INTESTINAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA). Journal of Zoo and Wildlife Medicine. 48(2), 568-572. https://doi.org/10.1638/20160221R.1