Journal article
Authors list: Heppt, Markus V.; Roesch, Alexander; Weide, Benjamin; Gutzmer, Ralf; Meier, Friedegund; Loquai, Carmen; Kaehler, Katharina C.; Gesierich, Anja; Meissner, Markus; von Bubnoff, Dagmar; Goeppner, Daniela; Schlaak, Max; Pfoehler, Claudia; Utikal, Jochen; Heinzerling, Lucie; Cosgarea, Ioana; Engel, Jutta; Eckel, Renate; Martens, Alexander; Mirlach, Laura; Satzger, Imke; Schubert-Fritschle, Gabriele; Tietze, Julia K.; Berking, Carola
Publication year: 2017
Pages: 36-44
Journal: European Journal of Cancer
Volume number: 81
ISSN: 0959-8049
eISSN: 1879-0852
DOI Link: https://doi.org/10.1016/j.ejca.2017.05.014
Publisher: Elsevier
Background: Mucosal melanoma (MM) is a rare but diverse cancer entity. Prognostic factors are not well established for Caucasians with MM. Patients and methods: We analysed the disease course of 444 patients from 15 German skin cancer centres. Disease progression was determined with the cumulative incidence function. Survival times were estimated with the Kaplan-Meier method. Prognostic parameters were identified with multivariate Cox regression analysis. Results: Common anatomic sites of primary tumours were head and neck (MMHN, 37.2%), female genital tract (MMFG, 30.4%) and anorectal region (MMAN, 21.8%). MMAN patients showed the highest vertical tumour thickness (p = 0.001), had a more advanced nodal status (p = 0.014) and a higher percentage of metastatic disease (p = 0.001) at diagnosis. Mutations of NRAS (13.8%), KIT (8.6%) and BRAF (6.4%) were evenly distributed across all tumour site groups. Local relapses were observed in 32.4% and most commonly occurred in the MMHN group (pZ0.016). Male gender (p = 0.047), advanced tumour stage (p = 0.001), nodal disease (p = 0.001) and incomplete resection status (p = 0.001) were independent risk factors for disease progression. Overall survival (OS) was highest in the MMFG group (p = 0.030) and in patients without ulceration (p = 0.004). Multivariate risk factors for OS were M stage at diagnosis (p = 0.002) and incomplete resection of the primary tumour (p = 0.001). Conclusion: In this large series of MM patients in a European population, anorectal MM was associated with the poorest prognosis. (C) 2017 Elsevier Ltd. All rights reserved.
Abstract:
Citation Styles
Harvard Citation style: Heppt, M., Roesch, A., Weide, B., Gutzmer, R., Meier, F., Loquai, C., et al. (2017) Prognostic factors and treatment outcomes in 444 patients with mucosal melanoma, European Journal of Cancer, 81, pp. 36-44. https://doi.org/10.1016/j.ejca.2017.05.014
APA Citation style: Heppt, M., Roesch, A., Weide, B., Gutzmer, R., Meier, F., Loquai, C., Kaehler, K., Gesierich, A., Meissner, M., von Bubnoff, D., Goeppner, D., Schlaak, M., Pfoehler, C., Utikal, J., Heinzerling, L., Cosgarea, I., Engel, J., Eckel, R., Martens, A., ...Berking, C. (2017). Prognostic factors and treatment outcomes in 444 patients with mucosal melanoma. European Journal of Cancer. 81, 36-44. https://doi.org/10.1016/j.ejca.2017.05.014
Keywords
CANCER CENTER; Immune checkpoint blockade; KIT; KIT EXPRESSION; MALIGNANT-MELANOMA; Mucosal melanoma; NECK; RETROSPECTIVE ANALYSIS; SINONASAL; staging; targeted therapy
