Journal article

Co-delivery of cisplatin and doxorubicin from calcium phosphate beads/matrix scaffolds for osteosarcoma therapy


Authors listHess, Ulrike; Shahabi, Shakiba; Treccani, Laura; Streckbein, Philipp; Heiss, Christian; Rezwan, Kurosch

Publication year2017

Pages427-435

JournalMaterials Science and Engineering: C

Volume number77

ISSN0928-4931

eISSN1873-0191

DOI Linkhttps://doi.org/10.1016/j.msec.2017.03.164

PublisherElsevier


Abstract
Bone substitute materials with a controlled drug release ability can fill cavities caused by the resection of bone tumours and thereby combat any leftover bone cancer cells. The combined release of different cytostatics seems to enhance their toxicity. In this study, calcium phosphate beads and matrix scaffolds are combined for a long-term co-delivery of cis-diamminedichloroplatinum (cisplatin, CDDP) and doxorubicin hydrochloride (DOX) as clinical relevant model drugs. Tricalcium phosphate/alginate beads as additional drug carrier are produced by droplet extrusion with ionotropic gelation and incorporated in scaffold matrix by freeze gelation without sintering. CDDP shows a short burst release while DOX has a continuous release measurable over the entire study period of 40 days. Drug release from matrix is decreased by similar to 30% compared to release from beads. Nevertheless, all formulations follow the Korsmeyer-Peppas release kinetic model and show Fickian diffusion. Cytotoxic activity was conducted on MG-63 osteosarcoma cells after 1, 4, and 7 days with WST-1 cell viability assay. Co-loaded composites enhance activity towards MG-63 cells up to similar to 75% toxicity while reducing the released drug quantity. The results suggest that co-loaded beads/matrix scaffolds are highly promising for osteosarcoma therapy due to synergistic effects over a long period of more than a month. (C) 2017 Elsevier B.V. All rights reserved.



Citation Styles

Harvard Citation styleHess, U., Shahabi, S., Treccani, L., Streckbein, P., Heiss, C. and Rezwan, K. (2017) Co-delivery of cisplatin and doxorubicin from calcium phosphate beads/matrix scaffolds for osteosarcoma therapy, Materials Science and Engineering: C, 77, pp. 427-435. https://doi.org/10.1016/j.msec.2017.03.164

APA Citation styleHess, U., Shahabi, S., Treccani, L., Streckbein, P., Heiss, C., & Rezwan, K. (2017). Co-delivery of cisplatin and doxorubicin from calcium phosphate beads/matrix scaffolds for osteosarcoma therapy. Materials Science and Engineering: C. 77, 427-435. https://doi.org/10.1016/j.msec.2017.03.164



Keywords


CisplatinCo-deliveryCOMBINATION CHEMOTHERAPYDOXORUBICINDrug carrierDRUG-DELIVERYKINETIC STABILITYSCAFFOLDSILICA NANOPARTICLESSODIUM ALGINATEVANCOMYCIN RELEASE

Last updated on 2025-21-05 at 18:29