Journal article
Authors list: Hess, Ulrike; Shahabi, Shakiba; Treccani, Laura; Streckbein, Philipp; Heiss, Christian; Rezwan, Kurosch
Publication year: 2017
Pages: 427-435
Journal: Materials Science and Engineering: C
Volume number: 77
ISSN: 0928-4931
eISSN: 1873-0191
DOI Link: https://doi.org/10.1016/j.msec.2017.03.164
Publisher: Elsevier
Abstract:
Bone substitute materials with a controlled drug release ability can fill cavities caused by the resection of bone tumours and thereby combat any leftover bone cancer cells. The combined release of different cytostatics seems to enhance their toxicity. In this study, calcium phosphate beads and matrix scaffolds are combined for a long-term co-delivery of cis-diamminedichloroplatinum (cisplatin, CDDP) and doxorubicin hydrochloride (DOX) as clinical relevant model drugs. Tricalcium phosphate/alginate beads as additional drug carrier are produced by droplet extrusion with ionotropic gelation and incorporated in scaffold matrix by freeze gelation without sintering. CDDP shows a short burst release while DOX has a continuous release measurable over the entire study period of 40 days. Drug release from matrix is decreased by similar to 30% compared to release from beads. Nevertheless, all formulations follow the Korsmeyer-Peppas release kinetic model and show Fickian diffusion. Cytotoxic activity was conducted on MG-63 osteosarcoma cells after 1, 4, and 7 days with WST-1 cell viability assay. Co-loaded composites enhance activity towards MG-63 cells up to similar to 75% toxicity while reducing the released drug quantity. The results suggest that co-loaded beads/matrix scaffolds are highly promising for osteosarcoma therapy due to synergistic effects over a long period of more than a month. (C) 2017 Elsevier B.V. All rights reserved.
Citation Styles
Harvard Citation style: Hess, U., Shahabi, S., Treccani, L., Streckbein, P., Heiss, C. and Rezwan, K. (2017) Co-delivery of cisplatin and doxorubicin from calcium phosphate beads/matrix scaffolds for osteosarcoma therapy, Materials Science and Engineering: C, 77, pp. 427-435. https://doi.org/10.1016/j.msec.2017.03.164
APA Citation style: Hess, U., Shahabi, S., Treccani, L., Streckbein, P., Heiss, C., & Rezwan, K. (2017). Co-delivery of cisplatin and doxorubicin from calcium phosphate beads/matrix scaffolds for osteosarcoma therapy. Materials Science and Engineering: C. 77, 427-435. https://doi.org/10.1016/j.msec.2017.03.164
Keywords
Cisplatin; Co-delivery; COMBINATION CHEMOTHERAPY; DOXORUBICIN; Drug carrier; DRUG-DELIVERY; KINETIC STABILITY; SCAFFOLD; SILICA NANOPARTICLES; SODIUM ALGINATE; VANCOMYCIN RELEASE