Journal article

Publication year: 2017

Pages: 230-251

Journal: Journal of the American College of Cardiology

Volume number: 70

Issue number: 2

ISSN: 0735-1097

eISSN: 1558-3597

Open access status: Green

DOI Link: https://doi.org/10.1016/j.jacc.2017.05.043

Publisher: Elsevier

Abstract: 
Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds endogenous antioxidant capacity. In this paper, we review the specific role of several cardiovascular risk factors in promoting oxidative stress: diabetes, obesity, smoking, and excessive pollution. Specifically, the risk of developing heart failure is higher in patients with diabetes or obesity, even with optimal medical treatment, and the increased release of ROS from cardiac mitochondria and other sources likely contributes to the development of cardiac dysfunction in this setting. Here, we explore the role of different ROS sources arising in obesity and diabetes, and the effect of excessive ROS production on the development of cardiac lipotoxicity. In parallel, contaminants in the air that we breathe pose a significant threat to human health. This paper provides an overview of cigarette smoke and urban air pollution, considering how their composition and biological effects have detrimental effects on cardiovascular health. (C) 2017 by the American College of Cardiology Foundation.

Harvard Citation style: Niemann, B., Rohrbach, S., Miller, M., Newby, D., Fuster, V. and Kovacic, J. (2017) Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution Part 3 of a 3-Part Series, Journal of the American College of Cardiology, 70(2), pp. 230-251. https://doi.org/10.1016/j.jacc.2017.05.043

APA Citation style: Niemann, B., Rohrbach, S., Miller, M., Newby, D., Fuster, V., & Kovacic, J. (2017). Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution Part 3 of a 3-Part Series. Journal of the American College of Cardiology. 70(2), 230-251. https://doi.org/10.1016/j.jacc.2017.05.043