Journalartikel
Autorenliste: Olsson, Karen M.; Wiedenroth, Christoph B.; Kamp, Jan-Christopher; Breithecker, Andreas; Fuge, Jan; Krombach, Gabriele A.; Haas, Moritz; Hamm, Christian; Kramm, Thorsten; Guth, Stefan; Ghofrani, Hossein Ardeschir; Hinrichs, Jan B.; Cebotari, Serghei; Meyer, Katrin; Hoeper, Marius M.; Mayer, Eckhard; Liebetrau, Christoph; Meyer, Bernhard C.
Jahr der Veröffentlichung: 2017
Zeitschrift: European Respiratory Journal
Bandnummer: 49
Heftnummer: 6
ISSN: 0903-1936
eISSN: 1399-3003
Open Access Status: Bronze
DOI Link: https://doi.org/10.1183/13993003.02409-2016
Verlag: European Respiratory Society
Balloon pulmonary angioplasty (BPA) is an emerging treatment for patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). We report on a prospective series of 56 consecutive patients who underwent 266 BPA interventions (median, five per patient) at two German institutions. All patients underwent a comprehensive diagnostic work-up including right heart catheterisation at baseline and 24 weeks after their last intervention. BPA resulted in improvements in WHO functional class, 6 min walk distance (mean change, + 33 m), right ventricular function and haemodynamics, including a decline in mean pulmonary artery pressure by 18% and in pulmonary vascular resistance by 26%. Procedure-related adverse events occurred in 9.4% of the interventions. The most common complications were related to pulmonary vascular injury and consecutive pulmonary bleeding. Most of these events were asymptomatic and self-limiting, but one patient died from pulmonary bleeding, resulting in a mortality rate of 1.8%. BPA resulted in haemodynamic and clinical improvements but was also associated with a considerable number of complications, including one fatal pulmonary bleeding. As the effects of BPA on survival are unknown, randomised controlled outcome trials comparing BPA with approved medical therapies in patients with inoperable CTEPH are required to allow for appropriate risk-benefit assessments.
Abstract:
Zitierstile
Harvard-Zitierstil: Olsson, K., Wiedenroth, C., Kamp, J., Breithecker, A., Fuge, J., Krombach, G., et al. (2017) Balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension: the initial German experience, European Respiratory Journal, 49(6), Article 1602409. https://doi.org/10.1183/13993003.02409-2016
APA-Zitierstil: Olsson, K., Wiedenroth, C., Kamp, J., Breithecker, A., Fuge, J., Krombach, G., Haas, M., Hamm, C., Kramm, T., Guth, S., Ghofrani, H., Hinrichs, J., Cebotari, S., Meyer, K., Hoeper, M., Mayer, E., Liebetrau, C., & Meyer, B. (2017). Balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension: the initial German experience. European Respiratory Journal. 49(6), Article 1602409. https://doi.org/10.1183/13993003.02409-2016
Schlagwörter
2015 ESC/ERS GUIDELINES; CHEST-2; ENDARTERECTOMY; INTERNATIONAL PROSPECTIVE REGISTRY; LONG-TERM EXTENSION; RIOCIGUAT
