Journal article

Publication year: 2017

Pages: 449-451

Journal: Experimental Dermatology

Volume number: 26

Issue number: 5

ISSN: 0906-6705

eISSN: 1600-0625

Open access status: Bronze

DOI Link: https://doi.org/10.1111/exd.13237

Publisher: Wiley

Abstract: 
Interleukin 10 (IL-10) has been implied in the regulation of allergic contact dermatitis. Using transcriptional reporter mice we analyzed cellular sources of IL-10 during contact hypersensitivity (CHS) and identified IL-10 expressing CD8(+) T cells in the skin that are antigen-specific, display PD-1, an effector memory phenotype, and IL-10 expression comparable to that of CD4(+) T cells. However, in mice with a selective IL-10 deficiency in CD8(+) T cells CHS responses were comparable to that of controls, even in the absence of CD4(+) cells, suggesting that CD8(+) T cell-derived IL-10 does not contribute significantly to the resolution of CHS responses.

Harvard Citation style: Dolch, A., Kunz, S., Dorn, B., Roers, A., Martin, S. and Jakob, T. (2017) Contact allergens induce CD8⁺ T cell-derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity, Experimental Dermatology, 26(5), pp. 449-451. https://doi.org/10.1111/exd.13237

APA Citation style: Dolch, A., Kunz, S., Dorn, B., Roers, A., Martin, S., & Jakob, T. (2017). Contact allergens induce CD8⁺ T cell-derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity. Experimental Dermatology. 26(5), 449-451. https://doi.org/10.1111/exd.13237